非编码RNA在口腔癌中的研究进展  

Advances of Non-coding RNA in Oral Cancer

作　　者：傅雨婷 杨汶峻 蒋斌元 FU Yuting;YANG Wenjun;JIANG Binyuan(Department of Clinical Laboratory,Medical Research Center,The Affiliated Changsha Central Hospital,Hengyang Medical School,University of South China,Changsha 410004,China)

机构地区：[1]南华大学附属长沙中心医院检验科,中心实验室,长沙410004

出　　处：《肿瘤防治研究》2022年第12期1296-1301,共6页Cancer Research on Prevention and Treatment

基　　金：国家自然科学基金青年科学基金(81802952);湖南省自然科学基金青年项目(2020JJ5608);湖南省研究生科研创新项目(CX20210982)。

摘　　要：口腔癌是一种常见的头颈部恶性肿瘤,其发病的分子机制复杂且尚需进一步探索。非编码RNA占人类转录本的95%以上,是口腔癌发生发展机制研究的重要切入点,非编码RNA中数量庞大的microRNA、lncRNA和circRNA通过不同的途径参与了生物体内绝大部分的生理病理进程,与mRNA和蛋白质共同构成了一个复杂的调控体系。本文总结了口腔癌相关非编码RNA的研究文献及最新进展,从microRNA、lncRNA和circRNA三个方面为口腔癌的研究及防治提供参考。Oral cancer is a common head and neck malignant tumor.Its molecular mechanism of pathogenesis is complex and needs further exploration.Non-coding RNAs account for more than 95%of human transcripts and include microRNAs,lncRNAs,and circRNAs.They are an important entry point for research on molecular mechanism of oral cancer.Non-coding RNAs and protein-coding genes constitute a complex regulatory system involved in the regulation of physiological and pathological processes.This review summarizes articles about oral cancer-related non-coding RNAs and presents valuable information from the perspectives of microRNA,lncRNA,and circRNA.

关 键 词：口腔癌 非编码RNA 小分子RNA 长链非编码RNA 环状RNA 

分 类 号：R739.8[医药卫生—肿瘤]