自拟升清益智汤治疗气虚痰阻型脑梗死后轻度血管性认知功能损害的效果  

Efficacy of self-made Shengqing Yizhi Decoction in the treatment of mild vascular cognitive impairment after cerebral infarction with qi deficiency and phlegm obstruction syndrome

作　　者：李福海 王雪红 刘灵 张小光 曹海芳 李向阳 赵汉青 LI Fuhai;WANG Xuehong;LIU Ling;ZHANG Xiaoguang;CAO Haifang;LI Xiangyang;ZHAO Hanqing(Department of Cerebral Diseases,Yixian Hospital of Traditional Chinese Medicine,Hebei Province,Yixian074200,China;College of Traditional Chinese Medicine,Hebei University,Hebei Province,Baoding071000,China)

机构地区：[1]河北省易县中医医院脑病科,河北易县074200 [2]河北大学中医学院,河北保定071000

出　　处：《中国医药导报》2022年第33期116-119,共4页China Medical Herald

基　　金：河北省中医药管理局中医药类科研计划课题(2021282)。

摘　　要：目的 探讨自拟升清益智汤治疗气虚痰阻型脑梗死后轻度血管性认知功能障碍患者的临床效果。方法 选取2021年1月至10月河北省易县中医院脑病科气虚痰阻型脑梗死后轻度血管性认知障碍患者172例为研究对象,使用随机数字表法将其分为对照组和治疗组,各86例。对照组给予尼麦角林、胞磷胆碱、奥拉西坦胶囊口服治疗;治疗组在对照组基础上加用自拟升清益智汤。两组总疗程均为3个月。比较两组治疗前后中医证候积分和认知水平变化情况。结果 研究中对照组脱落5例。治疗后两组中医证候总积分均较治疗前降低,且治疗组低于对照组,差异有统计学意义(P <0.05)。治疗后两组简明精神状态检查量表评分、蒙特利尔评分量表评分均较治疗前升高,且治疗组高于对照组,差异有统计学意义(P <0.05)。结论 自拟升清益智汤联合西药治疗血管性认知功能障碍效果显著,优于单纯口服西药。Objective To investigate the clinical efficacy of self-made Shengqing Yizhi Decoction in treating patients with mild vascular cognitive impairment after cerebral infarction with qi deficiency and phlegm obstruction syndrome. Methods A total of 172 patients with mild vascular cognitive impairment after cerebral infarction of qi deficiency and phlegm-blocked type in the Department of Cerebral Diseases, Yixian Hospital of Traditional Chinese Medicine of Hebei Province from January 2021 to October 2021 were selected as the research objects, and they were divided into control group and treatment group by random number table method, with 86 cases in each group. The control group was given Niergoline, Citicoline and Oxacetam Capsules for oral treatment. In the treatment group, self-made Shengqing Yizhi Decoction was added to based on the control group. The total treatment course of both groups was three months. The changes of traditional Chinese medicine syndromes and cognitive level were compared between the two groups before and after treatment. Results During the experiment, five patients in the control group fell off. After treatment, the total scores of traditional Chinese medicine syndrome in both groups were lower than those before treatment, and the treatment group was lower than the control group,the differences were statistically significant(P < 0.05). After treatment, the mini-mental state examination scores and montreal cognitive assessment scores of the two groups were higher than those before treatment, and the treatment group was higher than the control group, the differences were statistically significant(P < 0.05). Conclusion Shengqing Yizhi Decoction made at home mixed with western medicine is considerably more successful in treating vascular cognitive impairment than oral western medicine alone.

关 键 词：脑梗死 轻度血管性认知功能障碍 自拟升清益智汤 路志正 

分 类 号：R743.3[医药卫生—神经病学与精神病学]