阴道微生物群和宫颈癌前病变的相关性  

Correlation between vaginal microbiota and cervical precancerous lesions

作　　者：韩布威 刘洋 何慧 宫艺 刘宁 周丽娜 郝新颖 刘丽[3] HAN Buwei;LIU Yang;HE Hui;GONG Yi;LIU Ning;ZHOU Lina;HAO Xinying;LIU Li(Graduate School of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150040,China;Department of Traditional Chinese Medicine,Beilun Branch,the First Affiliated Hospital of Zhejiang University School of Medicine,Zhejiang Province,Ningbo315000,China;Ward Two,Department of Gynecology,the First Affiliated Hospital of Heilongjiang University of Chinese Medicine,Heilongjiang Province,Harbin150040,China)

机构地区：[1]黑龙江中医药大学研究生院,黑龙江哈尔滨150040 [2]浙江大学医学院附属第一医院北仑分院中医科,浙江宁波315000 [3]黑龙江中医药大学附属第一医院妇科二科,黑龙江哈尔滨150040

出　　处：《中国医药导报》2022年第33期49-52,共4页China Medical Herald

基　　金：教育部春晖计划合作科研项目(HLJ2019032)。

摘　　要：女性生殖道有一种与人体共生的微生物群,通常由乳酸杆菌属为优势菌,这种菌属在维持女性生殖道健康中起着重要作用。生殖道微生物群失调,会促进人乳头状瘤病毒(HPV)感染和宫颈上皮内瘤变(CIN)的发生发展,并最终导致宫颈恶性肿瘤。随着CIN严重程度的增加,优势乳酸杆菌的消耗会增加,这可能会对疾病消退率产生负面影响,比如会导致促炎环境,从而增加HPV E6和E7癌基因的表达和恶性细胞的增殖。本文就阴道微生物群的构成和宫颈癌的发生发展关系进行综述,以期更好地了解微生物群对宫颈癌影响,可能有助于探索新的宫颈癌诊断或预后微生物标志物,寻找新预防或治疗药物靶点。The female reproductive tract has a microbiome that lives in symbiosis with the human body, Lactobacillus is usually the dominant bacterium, this genus plays an important role in maintaining the health of the female reproductive tract.Dysregulation of reproductive tract microbiota may promote the development of human papillomavirus(HPV) infection and cervical intraepithelial neoplasias(CIN), and eventually lead to cervical malignancy. As the severity of CIN increases,depletion of dominant Lactobacillus increases, which may negatively affect the rate of disease regression, for example,leading to a pro-inflammatory environment that increases the expression of HPV E6 and E7 oncogenes and proliferation of malignant cells. This paper reviews the correlation between the composition of vaginal microbiota and the occurrence and development of cervical cancer, in order to better understand the influence of the microbiota on cervical cancer, which may contribute to explore new diagnostic or prognostic microbial markers of cervical cancer, and seek new prevention or treatment drug targets.

关 键 词：宫颈癌 阴道微生物 乳酸杆菌 人乳头瘤病毒 细菌性阴道炎 

分 类 号：R730[医药卫生—肿瘤]