六合丹辅助治疗重症急性胰腺炎临床研究  

Clinical Study on Liuhe Pellets in Adjuvant Treatment of Severe Acute Pancreatitis

作　　者：王青伟 孙柱 韩锦[1] 高劲松 WANG Qingwei;SUN Zhu;HAN Jin;GAO Jingsong

机构地区：[1]杭州市萧山区中医院重症监护室,浙江杭州311201

出　　处：《新中医》2022年第22期66-71,共6页New Chinese Medicine

摘　　要：目的:观察六合丹辅助治疗重症急性胰腺炎患者的效果。方法:选取100例重症急性胰腺炎肝胆湿热证或腑实热结证患者,按随机数字表法分为对照组和观察组各50例。2组均给予常规基础治疗联合早期益生菌添加肠内营养支持治疗,观察组加予六合丹湿敷腹部治疗,2组均连续治疗14 d。治疗前后评价2组患者的病情严重程度(Balthazar CT分级评分)、症状改善情况(症状积分)、肠黏膜屏障功能及免疫功能,比较2组的临床疗效。结果:治疗14 d后,观察组临床疗效总有效率90.00%,高于对照组(72.00%),差异有统计学意义(P<0.05)。2组症状积分、Balthazar CT分级评分均较治疗前降低(P<0.01),观察组2项评分均低于对照组(P<0.01)。2组二胺氧化酶、D-乳酸水平均较治疗前降低(P<0.01),观察组2项指标值均低于对照组(P<0.01)。2组CD4~+水平及CD4~+/CD8~+比值均较治疗前升高,CD8~+水平均较治疗前降低,差异均有统计学意义(P<0.01);观察组CD4~+水平及CD4~+/CD8~+比值均高于对照组,CD8~+水平低于对照组,差异均有统计学意义(P<0.01)。结论:应用六合丹辅助治疗重症急性胰腺炎肝胆湿热证或腑实热结证患者,有助于控制病情进展,改善肠黏膜屏障功能与免疫功能,提高疗效。Objective:To observe the effect of the therapy of Liuhe Pellets in the adjuvant treatment of severe acute pancreatitis. Methods: A total of 100 patients with severe acute pancreatitis with livergallbladder dampn-heat or bowel excess and heat bind syndrome were selected and divided into the control group and the observation group according to the random number table method, with 50 cases in each group. Both groups were treated with routine basic treatment and early enteral nutrition supplemented with probiotics, and the observation group was additionally given wet compressing with Liuhe Pellets. Both groups were treated for 14 days continuously. Before and after treatment,the improvement of symptoms and the severity of disease in the two groups were evaluated by the symptom scores and Balthazar CT classification score,and the intestinal mucosal barrier function and immune function were evaluated. The clinical effects were compared between the two groups. Results: After 14 days of treatment, the total clinical effective rate was 90.00% in the observation group, higher than that of 72.00% in the control group,the difference being significant(P<0.05). The symptom scores and Balthazar CT classification score in the two groups were decreased when compared with those before treatment(P<0.01),and the above two scores in the observation group were lower than those in the control group(P<0.01). The levels of diamine oxidase and D-lactate in the two groups were decreased when compared with those before treatment(P<0.01),and the above two levels in the observation group were lower than those in the control group(P<0.01). The levels of CD4and CD4/CD8in the two groups were increased when compared with those before treatment,and the levels of CD8were decreased,differences being significant(P<0.01);the levels of CD4and CD4/CD8in the observation group were higher and the level of CD8was lower than those in the control group, differences being significant(P<0.01). Conclusion: The application of Liuhe pellets in the adjuvant treatm

关 键 词：重症急性胰腺炎 肝胆湿热证 腑实热结证 六合丹 益生菌 肠黏膜屏障功能 免疫功能 

分 类 号：R576[医药卫生—消化系统]