补体系统在炎症性肠病发病中的作用  

The role of the complement system in the pathogenesis of inflammatory bowel disease

作　　者：曹辉[1] 刘素贤 温红珠[1] 林江[1] CAO Hui;LIU Su-xian;WEN Hong-zhu;LIN Jiang(Department of Gastroenterology,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学附属龙华医院消化科,上海200032

出　　处：《现代免疫学》2022年第6期527-531,共5页Current Immunology

基　　金：国家自然科学基金项目(81703986);上海市科学技术委员会科研计划项目(LH02.68.006)。

摘　　要：炎症性肠病(inflammatory bowel disease, IBD)是以肠道慢性炎症为病理特征的自身免疫性疾病。IBD慢性炎症的发生与肠道生理屏障完整性受损、化学屏障功能失调和免疫屏障稳态失衡有关。作为固有免疫重要组成的补体系统,可通过维持肠道生理屏障的完整性、化学屏障的功能和免疫屏障的稳态来保持肠道的正常结构。补体系统活化失衡可能是引起IBD肠道炎症的重要因素之一。该文从补体系统在肠屏障生理状态和IBD状态下所存在的差异,来对补体系统在IBD发病中的潜在作用进行阐述。Inflammatory bowel disease(IBD) is an autoimmune disease characterized by intestinal chronic inflammation. The onset of intestinal chronic inflammation in IBD is associated with the impaired integrity of the physiological barrier, the dysfunction of the chemical barrier, and the disorder of homeostasis of the immunological barrier of the intestine. As an important component of innate immunity, the complement system sustains the gut function by maintaining the integrity of the physiological barrier, the function of the chemical barrier, and the homeostasis of the immunological barrier of the intestine. The abnormal activation of the complement system may be one of the crucial factors causing intestinal inflammation in IBD. This review discusses the potential role of the complement system in the pathogenesis of IBD and summarized the differences between the physiological and IBD states of the intestinal barrier.

关 键 词：炎症性肠病 补体系统 肠屏障 稳态 

分 类 号：R574.1[医药卫生—消化系统]