伴有抑郁特征的首发精神分裂症患者巨噬细胞抑制因子与精神病理症状的关联性研究  

Relationship between macrophage inhibitory factor and psychotic symptoms in first-episode schizophrenia patients with depressive characteristics

作　　者：于健瑾[1] 宋佳起 赵青 王晓莹 高亚伦 辛闻 李红娜 付卫红[1] 周玲 林姿莹 王楠 陈大春[1] YU Jian-jin;SONG Jia-qi;ZHAO Qing;WANG Xiao-ying;GAO Ya-lun;XIN Wen;LI Hong-na;FU Wei-hong;ZHOU Ling;LIN Zi-ying;WANG Nan;CHEN Da-chun(Beijing Huilongguan Hospital,Beijing 100096,China)

机构地区：[1]北京回龙观医院,北京大学回龙观临床医学院,100096

出　　处：《临床精神医学杂志》2022年第6期442-444,共3页Journal of Clinical Psychiatry

基　　金：首都卫生发展科研专项项目(首发2018-2-2131)。

摘　　要：目的:探讨伴有抑郁特征的首发精神分裂症(FES)治疗前后巨噬细胞抑制因子(MIF)与精神病理症状的相关性。方法:FES患者112例,根据汉密尔顿抑郁量表(HAMD)总分分为伴或不伴抑郁亚组,同时纳入健康对照组58例。FES组接受利培酮单药治疗10周,采用阳性与阴性症状量表(PANSS)评定FES患者的精神病理症状。采用化学发光法检测FES组治疗前后及健康对照组血清MIF水平。结果:治疗前,FES组MIF水平显著高于正常对照组(P<0.01),伴抑郁组与不伴抑郁组一般精神病理分差异有统计学意义(P<0.01)。治疗后,不伴抑郁组MIF水平显著下降(P<0.05),伴抑郁组治疗后MIF水平差异无统计学意义,两组治疗前后PANSS总分及分量表分差异均有统计学意义。伴抑郁组基线及治疗后MIF水平与一般精神病理分均存在负相关(r_(1)=-0.34;r_(2)=-0.44),MIF变化值与一般精神病理分变化值存在负相关(r=-0.42)。结论:FES患者存在血清MIF水平异常,伴有抑郁特征FES患者的MIF与一般精神病理存在一定关联。Objective:To explore the correlation between macrophage migration inhibitory factor(MIF) levels and mental symptoms in first-episode schizophrenia(FES) patients accompanied with depressive symptoms.Method:A total of 112 FES patients and 58 healthy controls were included.And the FES group were divided into subgroups depending on accompanied with or without depression according to the Hamilton Depression Scale(HAMD).The FES group received risperidone monotherapy for 10 weeks,and the Positive and Negative Symptoms Scale(PANSS) was used to evaluate the psychopathological symptoms of FES patients.Chemiluminescence method was used to detect serum MIF levels before and after treatment in the FES group,while at baseline in the healthy control group.Results:Before treatment,the MIF levels in the FES group were significantly higher than those in the control group(P<0.01),and there was a significant difference in the general psychopathological scores between the depression and the non-depression group(P<0.01).After treatment,the MIF levels in the non-depression groupdecreased(P<0.05),while no difference found in the depression group.There were significant differences in the PANSS total score and subscale scores between before and after treatment in both groups.The MIF levels were negatively correlated with general psychopathological scores in PANSS at baseline or and after treatment(r_(1)=-0.34;r_(2)=-0.44) in the depression group.There was also a negative correlation between the changes of them(r=-0.42).Conclusion:The MIF levels in FES patients are abnormal,and there is a certain correlation between MIF and general psychopathology in FES patients with depressive characteristics.

关 键 词：精神分裂症 巨噬细胞抑制因子 抑郁 精神症状 

分 类 号：R749.4[医药卫生—神经病学与精神病学]