抑郁症抗炎治疗的研究进展  

Research progress on anti-inflammatory treatment of depression

作　　者：杨会增[1] 杨程皓[1] YANG Hui-zeng;YANG Cheng-hao(The Institute of Mental Health,Tianjin Mental Health Center,Tianjin Anding Hospital,Tianjin 300000,China)

机构地区：[1]天津市安定医院,300000

出　　处：《临床精神医学杂志》2022年第6期492-496,共5页Journal of Clinical Psychiatry

摘　　要：炎症因子参与抑郁症的发生发展,可有效预测抗抑郁药物治疗的应答情况;抗炎治疗的选择和疗效有赖于患者的炎症活性水平,伴有高炎症活性的抑郁症患者可从抗炎治疗中获益,而低炎症活性患者可能恶化症状。鉴于相关研究的局限性,当前很难将研究结论推广应用于抑郁症的临床诊疗。未来需开展更多高质量的研究进一步明确哪些患者可以从哪种抗炎治疗中获益。Inflammatory cytokines are involved in the pathophysiological process of depression and can effectively predict the response to antidepressant treatment;the application and efficacy of anti-inflammatory treatment are inflammatory-activity dependent,which means that combined treatment with anti-inflammatory treatment can help to improve depressive symptoms for depressed patients with high inflammatory activity,while the patients with a relative lower inflammatory activity could be worsen with it.In view of the limitations of related research till now,it is currently difficult to apply the research outcomes to the clinic practice of depression management.In the future,more high-quality studies are needed to further explore and confirm who could benefits from which anti-inflammatory treatments.

关 键 词：抑郁症 免疫炎症假说 巨噬细胞理论 炎症因子 抗炎治疗 

分 类 号：R749.4[医药卫生—神经病学与精神病学]