多形性脂肪肉瘤4例临床病理分析  

Pleomorphic liposarcoma:a clinicopathologic analysis of 4 cases

作　　者：刘喆 杨婕 朱萌 夏成茂 陈德义 舍雅莉 LIU Zhe;YANG Jie;ZHU Meng(Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China;不详)

机构地区：[1]甘肃中医药大学基础医学院,兰州730000 [2]兰州大学,兰州730000

出　　处：《中国处方药》2022年第12期14-16,共3页Journal of China Prescription Drug

基　　金：甘肃省自然科学基金(21JR11RA141)。

摘　　要：目的 探究多形性脂肪肉瘤临床病理特征、诊疗方法及复发转移情况。方法 分析4例PLPS患者临床资料、病理学特征及免疫表型,并复习有关文献。结果 患者年龄52~76岁,平均(64.5±8.5)岁,其中3例男性,1例女性;发病部位为纵隔、右腋窝、盆底和腹壁各1例。低倍镜下瘤细胞呈弥漫片状分布,伴坏死,细胞大小、形状不一,核畸形、深染;高倍镜下可见多边形、圆形、梭形及印戒样脂肪母细胞,灶性区域还可见诊断性的巨大多空泡脂肪母细胞,核深染,边缘有空泡压迹。肿瘤细胞表达S-100。结论 PLPS是一种多形性高度恶性肉瘤,也是脂肪肉瘤中较罕见的一类,镜下主要由多形性脂肪母细胞构成。治疗以手术切除为主,因其易复发、转移,故术后需定期随访观察。Objective To research the clinicopathologic traits, diagnosis and treatment, recurrence and metastasis of pleomorphic liposarcoma. Methods The clinical informations, pathological features and immunophenotype of 4 cases of pleomorphic liposarcoma in our hospital were analyzed retrospectively, and the literatures on the same subject were reviewed. Results The patients ranged in the age from 52 to 76 years, with an average of 64.5 years, including 3 males and 1 female, and the sites of disease were mediastinum, right axilla, pelvic floor and abdominal wall in 1 case each. Under the microscope, the cells of tumor were distributed in sheets, with massive necrosis,different cell sizes and shapes, nuclear malformation and deep staining;polygonal, round, triangular and impression-like lipoblasts were observed at high magnification, and diagnostic giant polyvacuolar lipoblasts were also observed in the area, with dark nuclei and vacuolar impression at the edge. Tumor cells express S-100. Conclusion PLPS is a pleomorphic highly malignant sarcoma and a rare type of liposarcoma.Surgical resection is the main treatment, because it is easy to relapse and metastasis, so regular follow-up observation is required after surgery.

关 键 词：多形性脂肪肉瘤 病理学 免疫组织化学 

分 类 号：R738.6[医药卫生—肿瘤]