己酮可可碱注射液联合丁苯酞软胶囊治疗急性脑梗死的疗效及对患者血清BNP、IGF-1水平的影响  

Efficacy of pentoxifylline injection combined with butylphthalide soft capsules in the treatment of acute cerebral infarction and its influence on the levels of serum BNP and IGF-1

作　　者：郑红亮 ZHENG Hong-liang(Cerebrovascular Department,Siping Ji'ao Brain Hospital,Siping 136000,China)

机构地区：[1]四平吉奥脑病医院脑血管病科,136000

出　　处：《中国实用医药》2022年第26期52-55,共4页China Practical Medicine

摘　　要：目的探讨己酮可可碱注射液联合丁苯酞软胶囊治疗急性脑梗死的疗效及对患者血清脑钠肽(BNP)、血清胰岛素样生长因子-1(IGF-1)水平的影响。方法138例急性脑梗死患者,按照随机数字表法分为观察组和对照组,各69例。对照组在常规综合治疗基础上口服丁苯酞软胶囊治疗,观察组在对照组治疗基础上加用己酮可可碱注射液治疗。比较两组治疗前后神经功能缺损情况、智力状况、认知功能、日常生活能力及BNP、IGF-1水平,治疗效果。结果治疗后,两组美国国立卫生研究院卒中量表(NIHSS)评分、简易智能智力状况检查量表(MMSE)评分及蒙特利尔认知评估量表(MoCA)评分均优于本组治疗前,且观察组NIHSS评分(4.28±0.51)分、MMSE评分(22.08±3.81)分及MoCA评分(21.15±3.57)分均优于对照组的(8.31±0.57)、(18.34±3.57)、(17.86±3.64)分,差异有统计学意义(P<0.05)。治疗后,两组日常生活活动能力量表(ADL)评分均高于本组治疗前,且观察组ADL评分(62.37±2.18)分显著高于对照组的(42.83±2.37)分,差异有统计学意义(P<0.05)。治疗后,两组IGF-1水平高于本组治疗前,BNP水平低于本组治疗前,且观察组IGF-1水平(178.95±8.27)μg/L高于对照组的(142.58±7.34)μg/L,BNP水平(176.38±21.19)pg/ml低于对照组的(238.81±24.81)pg/ml,差异有统计学意义(P<0.05)。观察组治疗优良率为94.20%,高于对照组的81.16%,差异有统计学意义(P<0.05)。结论己酮可可碱注射液联合丁苯酞软胶囊治疗急性脑梗死效果显著,可提高IGF-1水平,降低BNP水平,促进神经元再生,改善神经功能。Objective To discuss the efficacy of pentoxifylline injection combined with butylphthalide soft capsules in the treatment of acute cerebral infarction and its influence on the levels of serum brain natriuretic peptide(BNP)and insulin-like growth factor-1(IGF-1).Methods A total of 138 patients with acute cerebral infarction were divided into observation group and control group according to the random numerical table,with 69 cases in each group.The control group was treated with oral butylphthalide soft capsule on the basis of conventional comprehensive treatment,and the observation group was treated with pentoxifylline injection on the basis of the control group.The neurological deficits,intellectual status,cognitive function,activities of daily living,BNP and IGF-1 levels before and after treatment,and the therapeutic effects were compared between the two groups.Results After treatment,the National Institutes of Health Stroke Scale(NIHSS)score,Mini Mental Status Examination(MMSE)score and Montreal Cognitive Assessment(MoCA)score in both groups were better than those before treatment in this group;the NIHSS score(4.28±0.51)points,MMSE score(22.08±3.81)points and MoCA score(21.15±3.57)points in the observation group were better than(8.31±0.57),(18.34±3.57)and(17.86±3.64)points in the control group;the differences were all statistically significant(P<0.05).After treatment,the activities of daily living(ADL)scores in both groups were higher than those before treatment in this group,and the ADL score(62.37±2.18)points in the observation group was significantly higher than(42.83±2.37)points in the control group,and the difference was statistically significant(P<0.05).After treatment,the IGF-1 levels in both groups were higher than those before treatment in this group,and the BNP levels were lower than those before treatment in this group;the IGF-1 level(178.95±8.27)μg/L in the observation group was higher than(142.58±7.34)μg/L in the control group,and BNP level(176.38±21.19)pg/ml was lower than(238.81±24.

关 键 词：己酮可可碱 丁苯酞 急性脑梗死 胰岛素样生长因子-1 脑钠肽 

分 类 号：R743.3[医药卫生—神经病学与精神病学]