自身免疫性肝病相关抗体检测及其临床意义研究  

Study of autoimmune liver disease-related antibody test and its clinical significance

作　　者：付慧 赵子莹 FU Hui;ZHAO Zi-ying(Laboratory Department,Gansu Traditional Chinese Medicine Hospital,Lanzhou 730000,China)

机构地区：[1]甘肃省中医院检验科,730000

出　　处：《中国实用医药》2022年第26期80-82,共3页China Practical Medicine

摘　　要：目的探讨自身免疫性肝病(AILD)相关抗体检测的临床意义。方法选取100例自身免疫性肝病相关抗体检测的患者,依据初步诊断将50例自身免疫性肝病患者作为观察1组,将50例其他类型肝病患者作为观察2组;另选取50例常规体检健康者作为对照组。三组均进行自身免疫性肝病抗体谱检测,比较三组抗核抗体(ANA)、抗中性粒细胞胞浆抗体(ANCA)、抗可溶性肝抗原/肝胰抗原(SLA/LP)、肝肾微粒体1型(LKM-1)、肝细胞溶质抗原1型(LC-1)、抗线粒体抗体M2亚型(AMA-M2)、抗核膜糖蛋白210(gp210)、抗可溶性酸性核蛋白抗体(Sp100)的检出情况。结果观察1组ANA、ANCA、AMA-M2、SLA/LP、LKM-1、gp210、Sp100、LC-1检出率分别为76%、16%、30%、26%、10%、14%、16%、14%,均显著高于对照组的10%、2%、2%、0、0、0、0、0和观察2组的20%、4%、8%、10%、0、2%、2%、2%,差异有统计学意义(P<0.05);观察2组ANA、ANCA、AMA-M2、SLA/LP、LKM-1、gp210、Sp100、LC-1检出率与对照组比较,差异无统计学意义(P>0.05)。结论重视自身免疫性肝病相关抗体的检测,能极大提高其检出率,对自身免疫性肝病的早期诊断与鉴别诊断具有重要意义。Objective To discuss the clinical significance of autoimmune liver disease(AILD)-related antibody test.Methods 100 patients with autoimmune liver disease-related antibody test were selected,of which 50 patients with autoimmune liver disease were considered as observation group 1 and 50 patients with other types of liver disease were considered as observation group 2 according to the preliminary diagnosis;another 50 healthy subjects with regular physical examination were selected as the control group.All three groups were tested for autoimmune liver disease antibody profiles.The anti-nuclear antibody(ANA),anti-neutrophil cytoplasmic antibody(ANCA),anti-soluble liver antigen/liver pancreas antigen(SLA/LP),liver and kidney microsomes type 1(LKM-1),liver cytosol antigen type 1(LC-1),anti-mitochondrial antibody M2 subtype(AMA-M2),glycoprotein 210(gp210),and anti-soluble acid nuclear protein antibody(Sp100)were compared among the three groups.Results The detection rates of ANA,ANCA,AMA-M2,SLA/LP,LKM-1,gp210,Sp100,and LC-1 in the observation group 1 were 76%,16%,30%,26%,10%,14%,16%,and 14%,which were significantly higher than 10%,2%,2%,0,0,0,0,0,and 0 in the control group,and 20%,4%,8%,10%,0,2%,2%,2%in the observation group 2,and the differences were all statistically significant(P<0.05).There was no statistically significant difference in the detection rates of ANA,ANCA,AMA-M2,SLA/LP,LKM-1,gp210,Sp100,LC-1 between the observation group 2 and the control group(P>0.05).Conclusion Paying attention to the detection of antibodies related to autoimmune liver disease can greatly improve its detection rate,which is of great significance for the early diagnosis and differential diagnosis of autoimmune liver disease.

关 键 词：自身免疫性肝病 抗体检测 慢性肝病 诊断 

分 类 号：R575[医药卫生—消化系统]