HLA-DRA rs3129882多态性与帕金森病关系的meta分析  

Meta analysis on association between HLA-DRA rs3129882 polymorphism and Pakinson’s disease

作　　者：曹美群[1] 冯毅菲 蒋屏[3] 范大华 CAO Meiqun;FENG Yifei;JIANG Ping;FAN Dahua(Institute of Geriatrics,Shenzhen Municipal Second People’s Hospital,Shenzhen,Guangdong 518035,China;Graduate School of Guangxi University of Chinese Medicine,Nanning,Guangxi 530200,China;Department of Pediatrics,First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha,Hunan 410007,China;Shenzhen GenProMetab Biotechnology Co.,Ltd.,Shenzhen,Guangdong 518101,China)

机构地区：[1]广东省深圳市第二人民医院老年医学研究所,518035 [2]广西中医药大学研究生学院,南宁530200 [3]湖南中医药大学第一附属医院儿科,长沙410007 [4]深圳金普迈生物科技有限公司,广东518101

出　　处：《重庆医学》2022年第24期4252-4257,共6页Chongqing medicine

基　　金：国家自然科学基金项目(81603671);广东省深圳市科技规划项目(JCYJ20180508152437368);湖南省教育厅科学研究项目重点项目(18A217)。

摘　　要：目的研究Ⅱ类主要组织相容性复合体DRα(HLA-DRA)基因rs3129882位点多态性与帕金森病(PD)的遗传关联性。方法在Medline数据库和Google Scholar检索研究HLA-DRA rs3129882多态性与PD关系的英文文献并进行资料提取,检索时间为建库至2020年12月。采用RevMan 5.3、STATA11.0软件进行meta和统计学分析。通过优势比(OR)和95%可信区间(95%CI)评估关联度。结果最终纳入28项研究,共74715名研究对象,其中包含63778名高加索人(19509名PD患者,44269名健康对照者)和10937名亚洲人(4760名PD患者,6177名健康对照者)。高加索人HLA-DRA rs3129882位点多态性与PD明显相关(OR=1.04,95%CI:1.01~1.08,P=0.005);亚洲人HLA-DRA rs3129882变异与PD无关(OR=0.99,95%CI:0.87~1.12,P=0.82)。结论HLA-DRA rs3129882位点突变对PD发病的影响具有人种差异性,HLA-DRA rs3129882是高加索人而非亚洲人的PD易感突变位点。Objective To analyze the association between the HLA-DRA rs3129882 polymorphism and Parkinson’s disease(PD).Methods The English literatures on the relationship between HLA-DRA rs3129882 polymorphism and PD were retrieved from the MEDLINE database and Google Scholar,and the data were extracted.The retrieval time was from the database establishment to December 2020.The odds ratio(OR)and 95%confidence interval(CI)were calculated and the association degree was assessed.Results Twenty-eight studies were finally included,involving 74715 subjects(24269 cases of PD and 50446 healthy controls),among them,63778 subjects(19509 cases of PD and 44269 healthy controls)were Caucasian and 10937 subjects were Asian(4760 cases of PD and 6177 healthy controls).Caucasian HLA-DRA rs3129882 locus polymorphism was significantly correlated with PD(OR=1.04,95%CI:1.01-1.08,P=0.005);Asian HLA-DRA rs3129882 variation had no correlation with PD(OR=0.99,95%CI:0.87-1.12,P=0.82).Conclusion The HLA-DRA rs3129882 locus mutation has the race difference in PD onset.HLA-DRA rs3129882 is the susceptible mutation site for Caucasians rather than Asians.

关 键 词：Ⅱ类主要组织相容性复合体DRα 基因多态性 帕金森病 META分析 

分 类 号：R742.5[医药卫生—神经病学与精神病学]