乳腺癌组织中HER2、GCDFP15、Calponin表达及其与术后复发转移的关系  

Expression of HER2,GCDFP15 and Calponin in Breast Cancer Tissues and Their Relationship with Postoperative Recurrence and Metastasis

作　　者：凌云志 LING Yunzhi(Chaoyang Central Hospital,Liaoning Province,Chaoyang 122000,China)

机构地区：[1]辽宁省朝阳市中心医院,辽宁朝阳122000

出　　处：《中国医学创新》2022年第36期41-44,共4页Medical Innovation of China

摘　　要：目的:探讨乳腺癌患者标本组织内人表皮生长因子受体2(HER2)、巨囊性病液体蛋白15(GCDFP15)及钙调理蛋白(Calponin)表达及其与术后复发转移的相关性。方法:选取2018年1月-2020年10月朝阳市中心医院收治的91例乳腺癌患者。以免疫组化法检测并比较不同组织内的HER2、GCDFP15及Calponin表达情况。将所有受试者按照术后复发转移情况分成A组(复发转移)和B组(无复发转移)。对比两组临床资料和乳腺癌组织内的HER2、GCDFP15、Calponin表达情况及血清细胞角蛋白19片段抗原21-1(CYFRA21-1)及可溶性CD40配体(sCD40L)水平。采用多因素logistic回归分析乳腺癌患者术后复发转移相关影响因素。结果:乳腺癌组织中HER2、GCDFP15阳性表达率分别为65.93%、70.33%,均高于癌旁正常组织的21.98%、40.66%,而Calponin阳性表达率为27.47%,低于癌旁正常组织的72.53%(P<0.05)。多因素logistic回归分析可得:HER2阳性、GCDFP15阳性、血清CYFRA21-1、sCD40L水平均是乳腺癌患者复发转移的危险因素,而Calponin阳性为保护性因素(P<0.05)。结论:乳腺癌患者标本组织内HER2、GCDFP15、Calponin表达与其复发转移密切相关,可能成为预测患者复发转移的可靠指标。Objective:To analyze the expression of human epidermal growth factor receptor 2(HER2),local cystic liquid protein 15(GCDFP15) and Calponin in breast cancer tissues and their relationship with postoperative recurrence and metastasis.Method:A total of 91 patients with breast cancer admitted to Chaoyang Central Hospital from January 2018 to October 2020 were selected.The expressions of HER2,GCDFP15 and Calponin in different tissues were detected and compared by immunohistochemistry.All subjects were divided into group A(recurrence and metastasis) and group B(no recurrence and metastasis) according to postoperative recurrence and metastasis.Clinical data of the two groups and expressions of HER2,GCDFP15 and Calponin in breast cancer tissues as well as serum CYFRA21-1 and sCD40L levels were compared.Multivariate logistic regression was used to analyze the factors related to postoperative recurrence and metastasis of breast cancer patients.Result:The positive expression rates of HER2 and GCDFP15 in breast cancer tissues were 65.93% and 70.33%,which were higher than 21.98%and 40.66% in normal adjacent tissues,while the positive expression rate of Calponin was 27.47%,which was lower than 72.53% in normal adjacent tissues(P<0.05).Multivariate logistic regression analysis showed that positive HER2,positive GCDFP15,serum CYFRA21-1 and sCD40L levels were risk factors for recurrence and metastasis of breast cancer patients,while positive Calponin was protective factor(P<0.05).Conclusion:The expressions of HER2,GCDFP15 and Calponin in breast cancer specimens are closely related to their recurrence and metastasis,and may be reliable indicators for predicting recurrence and metastasis in patients.

关 键 词：乳腺癌 复发转移 人表皮生长因子受体2 巨囊性病液体蛋白15 钙调理蛋白 

分 类 号：R737.9[医药卫生—肿瘤]