发酵乳对肝硬化失代偿期患者肠黏膜屏障功能的影响  

Effect of fermented milk on intestinal mucosal barrier function in patients with decompensated liver cirrhosis

作　　者：白利梅[1] 梅璐[1] BAI Li-mei;MEI Lu(Department of Gastroenterology,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan 450014,China;不详)

机构地区：[1]郑州大学第五附属医院消化内科,河南郑州450014

出　　处：《中国微生态学杂志》2022年第10期1182-1185,共4页Chinese Journal of Microecology

基　　金：河南医学科技攻关项目(201702113);河南省科技英才海外研修工程项目(2018125);河南省重点研发与推广专项科技攻关项目(182102310179)。

摘　　要：目的观察发酵乳在改善肝硬化失代偿期患者肠黏膜屏障功能、肝功能及提高患者生活质量方面的作用。方法选择我院78例确诊为肝硬化失代偿期的患者,随机分成对照组和发酵乳组,其中对照组42例,发酵乳组36例。对照组患者给予常规综合治疗,发酵乳组在常规综合治疗的基础上给予口服发酵乳治疗,在治疗前及治疗4周后分别检测并比较两组患者肠黏膜屏障功能、血清白蛋白、血浆氨水平及慢性肝病问卷评分(CLDQ)的变化。结果治疗前两组患者肠屏障功能、血清白蛋白、氨水平及CLDQ评分差异无统计学意义(均P>0.05)。治疗4周后,发酵乳组患者血清内毒素、血清二胺氧化酶、D-乳酸及血浆氨水平较治疗前显著降低,较对照组治疗后亦降低(均P<0.05)。发酵乳组患者血清白蛋白水平及部分CLDQ评分较治疗前显著升高,较对照组治疗后亦升高(均P<0.05)。结论在常规综合治疗的基础上加用发酵乳可调节肝硬化失代偿期患者肠道菌群,改善肠黏膜屏障功能,从而保护肝脏功能,提高患者生活质量。Objective To observe the effects of fermented milk on intestinal mucosal barrier function and liver function of patients suffered decompensated liver cirrhosis(DLC).Methods A total of 78 cases of confirmed DLC in our hospital were randomly divided into control group(42 cases)or fermented milk group(36 cases).The patients in control group received conventional comprehensive therapy while those in the fermented milk group received conventional therapy combined with fermented milk.The indexes of intestinal mucosal barrier function and the levels of blood ammonia,serum albumin and chronic liver disease questionnaire(CLDQ)were observed and compared between groups before and four weeks after the treatment.Results Before the treatment,the intestinal mucosal barrier function and the levels of blood ammonia,serum albumin and CLDQ had no significant differences between the two groups.After the treatment,the levels of serum endotoxin,diamine oxidase,D-lactic acid and blood ammonia in fermented milk group were significantly lower than those before treatment and those in the control group,respectively.The levels of serum albumin and part of CLDQ in the fermented milk group were significantly higher than before treatment and those in the control group.Conclusion Conventional comprehensive therapy combined with fermented milk can effectively improve the intestinal mucosal barrier function,protect liver function and improve life quality by regulating the intestinal flora in patients with decompensated cirrhosis.

关 键 词：发酵乳 肝硬化失代偿期 血氨 肠黏膜屏障功能 血白蛋白 慢性肝病问卷评分 

分 类 号：R451[医药卫生—治疗学]