A systematic review on the safety of Psoraleae Fructus:potential risks,toxic characteristics,underlying mechanisms and detoxification methods  

作　　者：SHI Zhuo GAO Jing PAN Jinchao ZHANG Zuqi ZHANG Guangchen WANG Yuguang GAO Yue 

机构地区：[1]Department of Pharmaceutical Sciences,Beijing Institute of Radiation Medicine,Beijing 100850,China

出　　处：《Chinese Journal of Natural Medicines》2022年第11期805-813,共9页中国天然药物（英文版）

基　　金：supported by the Major Program of National Natural Science Foundation of China(Nos.82192910 and 82192911).

摘　　要：Psoraleae Fructus(PF)is an important traditional herbal medicine with a long history of clinical application.It is widely used to treat various diseases,such as osteoporosis,leucoderma and diarrhea.As a traditional nontoxic herb,it has aroused worldwide concern about the potential risks due to increasing adverse reaction events.This article reviews the botany,ancient records of medical uses,adverse reactions,toxicological research advance and detoxification methods of PF.According to clinical studies,liver injury is the most predominant in PF-related adverse reactions.The underlying mechanisms include bile acid metabolism and transport disorders,oxidative stress,mitochondrial damage,inhibition of liver cell regeneration and inflammatory reactions.Furthermore,the potential toxins of PF are summarized.Traditional methods of processing and compatibility will provide reference for reducing the toxicity of PF,which requires further research.In sum,this work systematically summarizes the reserach progress on the safety of PF,which will provide comprehensive insights into the toxicity of PF and facilitate its safe use and future development.

关 键 词：Psoraleae Fructus Toxic characteristics Detoxification compatibility Toxic substances HEPATOTOXICITY Psoralea corylifolia L. 

分 类 号：R965[医药卫生—药理学]