格拉斯哥预后评分与胃癌患者预后关系的Meta分析  

The relationship between Glasgow prognostic score and prognosis of gastric cancer patients:a meta-analysis

作　　者：赖佳敏 刘旭东 郑强 张国强 程志斌[2] 赵斌[2] LAI Jiamin;LIU Xudong;ZHENG Qiang;ZHANG Guoqiang;CHENG Zhibin;ZHAO Bin(Second Clinical Medical College of Lanzhou University,Lanzhou 730000,P.R.China;Department of General Surgery,the Second Hospital of Lanzhou University,Lanzhou 730000,P.R.China)

机构地区：[1]兰州大学第二临床医学院,兰州730000 [2]兰州大学第二医院普外科,兰州730000

出　　处：《中国循证医学杂志》2022年第11期1325-1329,共5页Chinese Journal of Evidence-based Medicine

摘　　要：目的系统评价格拉斯哥预后评分(GPS)与胃癌患者预后的关系。方法计算机检索PubMed、Web of Science、The Cochrane Library、CNKI、CBM和VIP数据库,搜集GPS与胃癌预后相关性的队列研究,检索时限均从建库至2022年4月。由2名研究者独立筛选文献、提取资料并评价纳入研究的偏倚风险后,采用RevMan 5.3软件、Stata 16.0软件进行Meta分析。结果共纳入9个队列研究,包括2395例患者。Meta分析结果显示:GPS1/2与胃癌患者总生存期显著相关[HR=2.01,95%CI(1.55,2.61),P<0.00001],且与更深的肿瘤深度、淋巴结转移阳性、更晚的TNM分期、远处转移阳性和高龄患者显著相关。结论当前证据显示,GPS与胃癌患者预后及临床病理学特征显著相关。受纳入研究数量和质量的限制,上述结论尚待更多高质量研究予以验证。Objective To systematically review the relationship between Glasgow prognostic score(GPS)and prognosis of gastric cancer(GC)patients.Methods PubMed,Web of Science,The Cochrane Library,CNKI,CBM and VIP databases were electronically searched to collect cohort studies on the relationship between GPS and prognosis of GC patients from inception to April,2022.Two reviewers independently screened literature,extracted data and assessed the risk of bias of included studies;then,meta-analysis was performed by using RevMan 5.3 software and Stata 16.0 software.Results A total of 9 cohort studies involving 2395 patients were included.The results of meta-analysis showed that GPS was significantly associated with poor overall survival of GC patients(HR=2.01,95%CI 1.55 to 2.61,P<0.00001).It also was associated with deeper depth of tumor,positive lymph node metastasis,more advanced TNM stages,positive distant metastasis and older age.Conclusion Current evidence shows that GPS is associated with survival prognosis and clinical pathological features of GC patients.Due to limited quality and quantity of the included studies,more high-quality studies are needed to verify the above conclusion.

关 键 词：格拉斯哥预后评分 胃癌 预后 META分析 系统评价 队列研究 

分 类 号：R735.2[医药卫生—肿瘤]