放射性药物在肿瘤靶向治疗中的应用  

Application of Radiopharmaceuticals in Targeted Tumor Therapies

作　　者：张桃桃 张红[1,2,3,4,5] 狄翠霞 ZHANG Tao-Tao;ZHANG Hong;DI Cui-Xia(Institute of Modern Physics,Chinese Academy of Sciences,Lanzhou 730000,China;Advanced Energy Science and Technology Guangdong Laboratory,Huizhou 516029,Guangdong,China;Key Laboratory of Heavy Ion Radiation Biology and Medicine,Chinese Academy of Sciences,Lanzhou 730000,China;Key Laboratory of Medical Application of Heavy Ion Beam Radiation in Gansu Province,Lanzhou 730000,China;Putian Lanhai Nuclear Medicine Research Center,Putian 351100,Fujing,China;College of Life Sciences,University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院近代物理研究所,兰州730000 [2]先进能源科学与技术广东省实验室,广东惠州516029 [3]中国科学院重离子束辐射生物医学重点实验室,兰州730000 [4]甘肃省重离子束辐射医学应用基础重点实验室,兰州730000 [5]莆田兰海核医学研究中心,福建莆田351100 [6]中国科学院大学生命科学学院,北京100049

出　　处：《中国生物化学与分子生物学报》2022年第11期1435-1442,共8页Chinese Journal of Biochemistry and Molecular Biology

基　　金：科技部国家重点研发计划(No.2018YFE0205100);国家自然科学基金联合重点项目(No.U1632270);国家自然科学基金面上项目(No.11675234)资助。

摘　　要：放射性药物指供临床诊断或治疗用的放射性核素制剂或其标记化合物。放射性核素靶向治疗是利用对肿瘤细胞具有特异高亲和力的分子载体将核素定向导入特定的肿瘤组织,对肿瘤进行治疗。与传统的放疗和化疗相比,其具有选择性杀伤肿瘤细胞的特点。随着核医学的发展,SPECT/CT、PET/CT的普及,新靶点的发现和新型放射性药物的研发,利用放射性药物进行靶向治疗在肿瘤临床治疗中占据的地位越来越重要。本文简述了放射性药物的分类、组成及特点;综述了针对肿瘤相关抗原的放射免疫药物在非霍奇金淋巴瘤、结直肠癌和前列腺癌中的应用;受体介导的放射性核素药物在治疗神经内分泌肿瘤、前列腺癌和乳腺癌中的临床应用以及基于基因修饰的放射性药物在肿瘤靶向治疗中的实验研究进展。最后总结了放射性药物在肿瘤靶向治疗中的应用前景与面临的挑战,以期为靶向治疗肿瘤的放射性药物的开发和临床应用提供一些参考。Radiopharmaceuticals are radionuclide preparations or radiolabelled compounds used for clinical diagnosis or treatment.The targeted radionuclide therapy uses molecular carriers with high affinity for tumor cells to target radionuclides into specific tumor tissues to treat tumors.Compared with traditional radiotherapy and chemotherapy,it is more selective.With the development of nuclear medicine,the popularization of SPECT/CT,PET/CT,the discovery of new targets and the development of new radiopharmaceuticals,the targeted therapy with radiopharmaceuticals is playing an increasingly important role in the clinical treatment of tumors.This review briefly describes the classification,composition and characteristics of radiopharmaceuticals;the application of radioimmunodrugs targeting tumor-associated antigen in non-Hodgkin’s lymphoma,colorectal cancer and prostate cancer;the clinical application of receptor-mediated radionuclide drugs in the treatment of neuroendocrine tumors,prostate cancer and breast cancer,and the research progress of radiopharmaceuticals based on gene modification in targeted tumor therapies.Finally,the application prospects and challenges of radiopharmaceuticals in cancer treatment are summarized in order to provide some references for the development and clinical application of radiopharmaceuticals for targeted tumor therapy.

关 键 词：放射性药物 肿瘤 靶向治疗 临床应用 

分 类 号：R730[医药卫生—肿瘤] Q691[医药卫生—临床医学]