2020年杭州市1859名体检人群的血浆氨基酸水平  

Plasma amino acids levels in 1859 physical examination subjects in Hangzhou City in 2020

作　　者：贺肖洁[1] 纪娜 黄晓旭 刘美萱 王佳利 孙婷[1] He Xiaojie;Ji Na;Huang Xiaoxu;Liu Meixuan;Wang Jiali;Sun Ting(Health Management Center,Second Affiliated Hospital of Zhejiang University,Hangzhou 310009,China;Department of Anesthesiology,Second Affiliated Hospital of Zhejiang University,Hangzhou 310009,China;Department of Nutriology,Second Affiliated Hospital of Zhejiang University,Hangzhou 310009,China;Department of Burns&Wound Care Center,Second Affiliated Hospital of Zhejiang University,Hangzhou 310009,China)

机构地区：[1]浙江大学医学院附属第二医院健康管理中心,杭州310009 [2]浙江大学医学院附属第二医院麻醉科,杭州310009 [3]浙江大学医学院附属第二医院营养科,杭州310009 [4]浙江大学医学院附属第二医院烧伤和创面修复科,杭州310009

出　　处：《卫生研究》2022年第6期996-1001,共6页Journal of Hygiene Research

摘　　要：目的 探讨体检人群空腹血浆游离氨基酸水平与肥胖之间的关系。方法 纳入1859名2020年1—12月在浙江大学医学院附属第二医院健康体检的人群为研究对象,使用超高效液相色谱串联质谱法与Inbody仪器分别测定体检人群的空腹血浆氨基酸浓度与体脂率,根据体质指数及性别分组,使用Python语言进行数据分析及图形可视化来探究体质指数、性别与血浆氨基酸水平之间的关系。结果 血浆甘氨酸、丝氨酸和天门冬酰胺水平在体重超重、肥胖组明显低于体重正常组(P<0.05),且男性肥胖组明显低于超重组(P<0.05);赖氨酸、色氨酸、精氨酸和羟基脯氨酸血浆水平变化在正常、超重和肥胖组差异均无统计学意义(P>0.05);血浆亮氨酸、缬氨酸、酪氨酸、苯丙氨酸(男性)和丙氨酸水平超重、肥胖组明显高于正常组(P<0.05),除丙氨酸外肥胖组显著高于超重组(P<0.05);异亮氨酸在女性超重、肥胖组比正常组有明显升高(P<0.05)。体脂率与体质指数呈正相关,且女性50岁后体脂率随年龄递增明显(P<0.05)。结论 该体检人群的超重肥胖率偏高。OBJECTIVE To study the relationship between fasting plasma amino acids and obesity in the physical examination population.METHODS A total of 1859 persons who underwent physical examination in the Second Affiliated Hospital Zhejiang University School of Medicine from January to December 2020 were enrolled. Fasting plasma amino acids concentrations and body fat ratio(BFR) were respectively determined by ultra-performance liquid chromatography tandem mass spectrometry(UPLC-MS/MS) and Inbody instrument. According to body mass index and gender grouping, Python language was used for data analysis and graphic visualization to explore the relationship between body mass index, gender and plasma amino acids levels.RESULTS The plasma levels of glycine, serine and asparagine in the overweight and obesity groups were significantly lower than those in the normal group, especially the levels in the obesity group were lower than those in the overweight group in males(P<0.05). There was no significant difference in plasma levels of lysine, tryptophan, arginine and hydroxyproline among normal, overweight and obesity groups(P>0.05). The plasma levels of leucine, valine, tyrosine, phenylalanine(in males),isoleucine(in females) and alanine in the overweight and obesity groups were significantly higher than those in the normal group, and the levels in the obesity group were higher than those in the overweight group except alanine(P<0.05). BFR was positively correlated with body mass index. BFR in females increased significantly with age after 50 years old(P<0.05).CONCLUTION The rate of overweight and obesity among the health screening population is high.

关 键 词：血浆氨基酸 肥胖 体检人群 

分 类 号：R151.4[医药卫生—营养与食品卫生学] R153[医药卫生—公共卫生与预防医学]