腹腔灌注化疗序贯深部热疗联合全身静脉化疗对局部晚期结直肠癌患者疗效及预后的影响  

Effect of intraperitoneal perfusion chemotherapy combined with sequential deep hyperthermia and systemic intravenous chemotherapy on the efficacy and prognosis of patients with locally advanced colorectal cancer

作　　者：张翔 周效旺 王之霞 李伟 孙立柱 Zhang Xiang;Zhou Xiaowang;Wang Zhixia;Li Wei;Sun Lizhu(Department of oncology,Shuyang hospital affiliated to Xuzhou Medical University,Suqian,Jiangsu,223600,China)

机构地区：[1]沭阳医院肿瘤科,江苏宿迁223600

出　　处：《齐齐哈尔医学院学报》2022年第20期1912-1915,共4页Journal of Qiqihar Medical University

基　　金：江苏省卫生健康委科研项目(M2021096)。

摘　　要：目的探讨腹腔灌注化疗序贯深部热疗联合全身静脉化疗对局部晚期结直肠癌患者疗效及预后的影响。方法采用回顾性分析方法,选择2016年1月-2019年1月本院收治的84例局部晚期结直肠癌接受根治术后的患者为研究对象,根据治疗方法不同分为常规组和观察组两组,每组各42例。常规组分次给予全身静脉化疗,观察组采用腹腔灌注化疗序贯深部热疗联合全身静脉化疗治疗,观察两组患者3年DFS率,统计两组治疗前后卡氏功能状态(KPS)评分以及治疗期间不良反应发生情况、预后情况。结果观察组3年DFS率为83.33%,高于常规组的64.29%,差异有统计学意义(P<0.05)。两组治疗前比较,KPS评分差异无统计学意义(P>0.05);治疗后两组均提高,观察组KPS评分比常规组高,差异有统计学意义(P<0.05)。观察组治疗期间不良反应发生率为14.29%,与常规组的7.14%比较,差异无统计学意义(P>0.05)。两组患者预后情况对比,差异有统计学意义(P<0.05)。观察组远处转移、局部复发均低于常规组(P<0.05)。结论对局部晚期结直肠癌患者应用腹腔灌注化疗序贯深部热疗联合全身静脉化疗,提高患者的生存率,提高患者生活质量,安全可靠。Objective To investigate the effect of intraperitoneal perfusion chemotherapy followed by sequential deep hyperthermia combined with systemic intravenous chemotherapy on the curative effect and prognosis of patients with locally advanced colorectal cancer.Methods According to retrospective analysis method,84 patients suffered with locally advanced colorectal cancer and received radical operation,those were admitted to our hospital from January 2016 to January 2019 were selected as study subjects.According to different treatment methods,they were divided into two groups:routine group and observation group,with 42 patients in each group.Patients in the the routine group was given systemic intravenous chemotherapy in several times.Patients in the observation group were treated with intraperitoneal perfusion chemotherapy and sequential deep hyperthermia combined with systemic intravenous chemotherapy.The 3-year DFS rate of the patients in the two groups was observed,and the Kaplan functional status(KPS)scores before and after treatment,the occurrence of adverse reactions and the prognosis of the two groups were statistically analyzed.Results the 3-year DFS rate of the observation group was 83.33%,which was higher than 64.29%of the routine group(P<0.05).There was no significant difference in KPS score between the two groups before treatment(P>0.05).After treatment KPS score of the two groups were increased,and the KPS score of the observation group was higher than that of the routine group(P<0.05).The incidence of adverse reactions in the observation group was 14.29%,and it was 7.14%in the conventional group,there was no significant differencebetween the two groups(P>0.05).The difference in prognosis of the two groups was statistically significant(P<0.05).The incidence of distant metastasis and local recurrence in the observation group were lower than those in the routine group(P<0.05).Conclusions It is safe and reliable to apply intraperitoneal perfusion chemotherapy and sequential deep hyperthermia combined with sys

关 键 词：腹腔灌注化疗 深部热疗 全身静脉化疗 局部晚期结直肠癌 不良反应 

分 类 号：R734.2[医药卫生—肿瘤]