子宫颈腺癌最新分型标准及临床病理联系  

The latest classification criteria and clinicopathological association of cervical adenocarcinoma

作　　者：王玄 俞岚[1] Wang Xuan;Yu Lan(Department of Pathology,The First Affiliated Hospital of Bengbu Medical College;Department of Pathology,Bengbu Medical College;Anhui Key Laboratory of Infection and Immunity,Bengbu Medical College)

机构地区：[1]蚌埠医学院第一附属医院病理科,蚌埠医学院病理学教研室,蚌埠医学院安徽省感染与免疫重点实验室,233000

出　　处：《齐齐哈尔医学院学报》2022年第20期1969-1974,共6页Journal of Qiqihar Medical University

摘　　要：子宫颈腺癌(cervical adenocarcinoma,CA)是一组异质性显著的肿瘤,由不同的组织亚型组成,并具有不同的病因和临床结果。CA是仅次于子宫颈鳞状细胞癌(squamous cell carcinoma,SCC)的第二大子宫颈癌类型。目前,宫颈细胞学筛查的普遍开展和抗人类乳头状瘤病毒(human papillomavirus,HPV)疫苗的广泛应用,SCC的发病率呈现下降趋势,而CA的相对或绝对发病率呈现明显增长。2018年新提出的国际子宫颈腺癌标准与分类(International Endocervical Adenocarcinoma Criteria and Classification,IECC)分型和2020年WHO分型在临床分期方面具有更好的诊断重复性,有望在未来替代2014年WHO分型。大多数CA与HPV感染相关,越来越多的学者更倾向于应用Sliva分型,其优势在于仅通过镜下形态就可将HPV相关性(HPV-associated,HPVA)宫颈腺癌分为三种类型,且临床诊治精确度更高。我们通过分析比较2014年关于CA的世界卫生组织(World Health Organization,WHO)女性生殖系统肿瘤分类、IECC(2018)分类,2020年WHO分型以及Silva模式分类系统的发展及变化,希望能够对于CA的临床治疗和预后判断提供一定的帮助。Cervical adenocarcinoma(CA)is a heterogeneous group of tumors composed of different tissue sub-types,with different etiology and clinical outcomes.CA is the second most common type of cervical cancer after squamous cell carcinoma(SCC).The prevalence of cervical cytology screening and the widespread use of the vaccine against human papillomavirus(HPV)have led to a decline in SCC incidence,however,a significant increase in the relative or absolute incidence of CA.The new international standard for the cervical adenocarcinoma and classification(International endocervical adenocarcinoma criteria and classification,IECC)that put forward in 2018 and the 2020WHO classificationhave better diagnostic repeatability in clinical staging and are expected to replace the 2014 WHO classificationin the future.The majority of CA is associated with HPV infection,and more and more scholars prefer to use Sliva typing,which has the advantage that HPV-associated(HPVA)cervical adenocarcinoma can be divided into three types only by microscopic morphology,and the clinical diagnosis and treatment accuracy is higher.We analyzed and compared the development and changes of the World Health Organization(WHO)classification of female reproductive system tumors in 2014,IECC(2018)classification,2020WHO classification and Silva model classification system.Hope to provide some help for the clinical treatment and prognosis of CA.

关 键 词：子宫颈腺癌 国际子宫颈腺癌标准和分类 Sliva分型 

分 类 号：R737.33[医药卫生—肿瘤]