肿瘤休眠的周期和意义  

The cycle of dormant cancer cells

作　　者：张百红 岳红云 ZHANG Baihong;YUE Hongyun(Department of Oncology,the 940th Hospital of Joint Logistics Support Force of People's Liberation Army,Gansu Lanzhou 730050,China;Department of Ophtalmology,the 940th Hospital of Joint Logistics Support Force of People's Liberation Army,Gansu Lanzhou 730050,China)

机构地区：[1]解放军联勤保障部队第九四〇医院肿瘤科,甘肃兰州730050 [2]解放军联勤保障部队第九四〇医院眼科,甘肃兰州730050

出　　处：《现代肿瘤医学》2023年第2期392-394,共3页Journal of Modern Oncology

基　　金：中国人民解放军联勤保障部队九四〇医院院内课题(编号:2021yxky052)。

摘　　要：休眠细胞是可逆的静止期细胞,肿瘤休眠细胞的生命周期包括休眠、复苏、出芽和种植,这个周期构成了肿瘤复发的根源。继续维持细胞休眠状态、杀灭肿瘤休眠细胞和诱导休眠细胞衰老的靶向肿瘤休眠策略将可能预防肿瘤复发。Cell dormancy is a reversible quiescence state.The dormant cancer cells life cycle have quiescence,reawakening,budding,and seeding four phases,which can cause cancer relapse.The current strategies targeting cancer cell dormancy include keeping cancer cells in the dormant state,eradicating dormant cancer cells and inducing dormant cancer cells to enter senescent state.

关 键 词：肿瘤休眠 肿瘤出芽 肿瘤苏醒 治疗 

分 类 号：R730.5[医药卫生—肿瘤]