B7-H5/CD28H在恶性肿瘤发生发展中的研究进展  

Research progress of B7-H5/CD28H in the occurrence and development of malignant tumors

作　　者：王俊旗 徐锋[1] WANG Junqi;XU Feng(Department of General Surgery,Shengjing Hospital of China Medical University,Liaoning Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院普通外科,辽宁沈阳110004

出　　处：《现代肿瘤医学》2023年第2期373-376,共4页Journal of Modern Oncology

基　　金：辽宁省自然科学基金项目(编号:20180551193,2020-MS-181);盛京医院345人才工程计划(编号:40B)。

摘　　要：B7-H5/CD28H是新近发现的免疫抑制信号通路,通过调节T细胞和NK细胞功能、细胞黏附以及血管生成等方式在恶性肿瘤的发生发展过程中发挥着作用。而且,B7-H5与CD28H表达水平与恶性肿瘤的预后密切相关。本文就B7-H5和CD28H的结构、功能及其表达水平与恶性肿瘤的预后关系进行综述,以期探究该信号通路在恶性肿瘤免疫治疗中的应用前景。B7-H5/CD28 H is a newly discovered immunosuppressive signal pathway,which plays a role in the occurrence and development of malignant tumors by regulating T cells and NK cells functions,cell adhesion and angiogenesis.Moreover,the expression levels of B7-H5 and CD28 H are closely related to the prognosis of malignant tumors.In this article,not only the structure and function of B7-H5 and CD28 H but also the relationship between B7-H5/CD28 H expression levels and the prognosis were reviewed,in order to explore the application prospect of this signaling pathway in the immunotherapy of malignant tumors.

关 键 词：免疫抑制 信号通路 B7-H5 CD28H 恶性肿瘤 免疫治疗 

分 类 号：R730.231[医药卫生—肿瘤]