miRNAs调控E2F5在癌症发生发展中的作用及其机制研究进展  

Research progress on the role and mechanism of miRNAs through regulating E2F5 in the tumorigenesis and development of cancer

作　　者：李婷婷[1] 朱心怡 李思浓 邵阳光[2] LI Tingting;ZHU Xinyi;LI Sinong;SHAO Yangguang(China Medical University,Liaoning Shenyang 110122,China;Department of Molecular Cell Biology,School of Life Sciences,China Medical University,Key Laboratory of Cell Biology,National Health and Family Planning Commission and Key Laboratory of Medical Cell Biology,Ministry of Education,China Medical University,Liaoning Shenyang 110122,China)

机构地区：[1]中国医科大学,辽宁沈阳110122 [2]中国医科大学生命科学学院分子细胞生物学教研室,国家卫生和计划生育委员会细胞生物学重点实验室暨教育部医学细胞生物学重点实验室,辽宁沈阳110122

出　　处：《现代肿瘤医学》2023年第2期367-373,共7页Journal of Modern Oncology

基　　金：辽宁省自然科学基金(编号:2019-MS-380);2020年中国医科大学大学生创新训练项目(编号:111251703)。

摘　　要：E2F转录因子5(E2F transcription factor 5,E2F5)是腺病毒E2启动子结合因子(adenovirus E2 promoter binding factor,E2F)转录因子家族的一员,参与细胞增殖、分化和凋亡等多种重要细胞过程。由于E2F5在细胞周期调控中发挥重要作用,因此它与多种癌症的发生,发展和预后密切相关。近来随着对微小RNA(microRNAs,miRNAs)研究的进展,发现多种miRNAs通过靶向E2F5来影响肿瘤细胞的增殖、凋亡、迁移、侵袭和耐药。本文结合最新研究报道,对E2F5在癌症中的研究进展,特别是不同肿瘤中miRNAs与E2F5之间的关系作一综述,为制定癌症的治疗策略提供新的思路。E2 F transcription factor 5(E2 F5)is a member of the adenovirus E2 promoter binding factor(E2 F)transcription factor family,involved in many important cellular processes,including cell proliferation,differentiation and apoptosis.Given its important roles in cell cycle regulation,E2 F5 is closely associated with the tumorigenesis,progression and prognosis of various types of cancer.Recently,with the research progress of miRNAs(microRNAs),many miRNAs are found to affect the proliferation,apoptosis,migration,invasion and drug resistance of tumor cells by targeting E2 F5.This article summarizes the research progress of E2 F5 in cancer in combination with the latest research reports,especially the link between miRNAs and E2 F5 in various cancers,providing new ideas for potential cancer therapeutic strategies.

关 键 词：E2F5 E2F转录因子 MIRNAS 癌症 

分 类 号：R730.231[医药卫生—肿瘤]