Gastrointestinal microbiome and primary Sjogren’s syndrome: a review of the literature and conclusions  

作　　者：Yu-Feng Yao Mei-Ying Wang Xiao-Yan Dou 

机构地区：[1]Department of Ophthalmology,Shenzhen Second People's Hospital,the First Affiliated Hospital of Shenzhen University,Shenzhen 518035,Guangdong Province,China [2]Shantou University Medical College,Shantou 515031,Guangdong Province,China [3]Department of Rheumatology and Immunology,Shenzhen Second People's Hospital,the First Affiliated Hospital of Shenzhen University,Shenzhen 518035,Guangdong Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2022年第11期1864-1872,共9页国际眼科杂志（英文版）

基　　金：Supported by the Science and Technology Program for Basic Research in Shenzhen (No.JCYJ20200109140412476);Clinical Research Project of Shenzhen Second People’s Hospital in 2019 (No.20193357009)。

摘　　要：The recognition of the profound impact of the human gastrointestinal microbiome(GM) on human autoimmune diseases has gradually increased thanks to deeper research efforts. As a systemic autoimmune disease, primary Sjogren’s syndrome(pSS) cannot be completely cured. Human studies have revealed that GM species and diversity are altered in patients with p SS compared with healthy individuals. Animal studies have provided possible mechanisms for the association between pSS and GM. The potential role of GM in pSS is exerted through several mechanisms. GM dysbiosis leads to increased intestinal permeability, which increases the risk of GM antigen exposure and activates specific autoreactive T lymphocytes via “molecular mimicry”. In addition, GM antigen exposure and intestinal immune tolerance loss caused by GM dysbiosis together induce chronic local gut mucosal inflammation, which deteriorates to systemic chronic non-specific inflammation with the circulation of pro-inflammatory lymphocytes and cytokines. These factors eventually activate autoreactive B lymphocytes and lead to pSS. If GM plays a key role in the pathogenesis of pSS, clarifying the underlying mechanisms will be helpful for the development of new therapies targeting GM for dry eye associated with pSS. This review summarizes the latest knowledge about the relationship between GM and p SS,with the aim of contributing to future research and to the development of new clinical applications.

关 键 词：gastrointestinal microbiome primary Sjogren’s syndrome dry eye DYSBIOSIS AUTOIMMUNITY clinical therapy 

分 类 号：R593.2[医药卫生—内科学]