威海区域性大数据管理肺癌队列的临床特征和生存情况  

Clinical characteristics and survival of lung cancer cohort based on Weihai regional big data management

作　　者：张蓝方 王丽洁 张明娟[1] 刘爱玲[1] 郭晓雷[3] 于进超[1] 孙珊珊[1] 曹树伟[1] 季怀君 冯虎 姜轶男 李静宜 杨柳[1] 于鑫 齐越 薛付忠 杨福俊[1] Zhang Lanfang;Wang Lijie;Zhang Mingjuan;Liu Ailing;Guo Xiaolei;Yu Jinchao;Sun Shanhsan;Cao Shuwei;Ji Huaijun;Feng Hu;Jiang Yinan;Li Jingyi;Yang Liu;Yu Xin;Qi Yue;Xue Fuzhong;Yang Fujun(Department of Oncology,Weihai Municipal Hospital,Weihai 264200,China;Epidemiology and Health Statistics,School of Public Health,Cheeloo College of Medicine,Shandong University,Jinan 250000,China;Institute of Chronic Disease Control,Shandong Center for Disease Control and Prevention,Jinan 250000,China)

机构地区：[1]威海市立医院肿瘤科,威海264200 [2]山东大学齐鲁医学院公共卫生学院生物统计系,济南250000 [3]山东省疾病预防控制中心慢病防治所,济南250000

出　　处：《国际流行病学传染病学杂志》2022年第5期298-302,共5页International Journal of Epidemiology and Infectious Disease

摘　　要：目的依托大数据技术建立一个以威海市立医院为基础的肺癌纵向队列,用于了解该院肺癌就诊患者的临床特征及生存情况。方法以2016年1月至2021年5月在威海市立医院诊断为肺癌的5246例患者为研究对象,利用大数据平台获取所纳入患者的诊断程序、病理学、治疗、复发日期以及死亡日期等信息。采用描述性分析和生存曲线进行生存分析。结果5246例患者中位年龄63岁,男性占51.94%,吸烟者占18.28%,非小细胞肺癌占比89.88%,其中腺癌82.88%,小细胞肺癌占比7.97%。Ⅰ期病例2497例(47.60%),Ⅱ期294例(5.60%),Ⅲ期781例(14.89%),Ⅳ期1450例(27.64%),分期未知224例(4.27%)。以肺癌确诊时间为起点,死亡时间或最后随访时间为终点,威海市立医院肺癌队列的患者平均5年生存率52.77%,中位生存时间5.37年。通过生存曲线分析,肺腺癌预后最好(5年生存率为65.53%),小细胞肺癌预后最差(5年生存率为15.51%)。结论威海市肺癌患者以非小细胞肺癌为主,肺腺癌预后相对较好。威海市立医院肺癌队列作为一个以医院为基础的专病纵向队列,纳入病例数充足、提取信息量大,客观反映了威海地区肺癌患者的临床特征及生存情况,具备有效性和区域特性。Objective To establish a Weihai Municipal Hospital lung cancer cohort based on big data technology,so as to understand the clinical characteristics and survival of patients with lung cancer in this hospital.Methods From January 2016 to May 2021,5246 patients diagnosed with lung cancer in Weihai Municipal Hospital were enrolled as the research objects,and the information about the diagnosis procedure,pathology,treatment,recurrence date and death date was obtained from the big data platform.Descriptive analysis and survivorship curve were used for survival analysis.Results The median age of 5246 patients was 63 years old.Males and smokers accounted for 51.94%and 18.28%,respectively.Patients with non-small cell lung cancer accounted for 89.88%,including 82.88%of adenocarcinoma and 7.97%of small cell lung cancer.There were 2497 cases(47.60%)in stageⅠ,294 cases(5.60%)in stageⅡ,781 cases(14.89%)in stageⅢ,1450 cases(27.64%)in stageⅣ,and 224 cases(4.27%)in unknown stage.Taking the time of diagnosis of lung cancer as the starting point,the time of death or the last follow-up time as the end point,the average 5-year survival rate of lung cancer patients was 52.77%,and the median survival time was 5.37 years.By survivorship curve analysis,the prognosis of lung adenocarcinoma was the best(5-year survival rate of 65.53%),and the prognosis of small cell lung cancer was the poorest(5-year survival rate of 15.51%).Conclusions Non-small cell lung cancer is the main type of lung cancer in Weihai,and the prognosis of lung adenocarcinoma is relatively good.As a hospital-based longitudinal cohort of specific diseases,the Weihai Municipal Hospital lung cancer cohort has the sufficient number of cases and large amount of extracted information.It objectively reflects the clinical characteristics and survival of lung cancer patients in Weihai,and has reliable effectiveness and regional characteristics.

关 键 词：肺肿瘤 队列 大数据 平台 生存 

分 类 号：R734.2[医药卫生—肿瘤]