同源重组修复蛋白Rad51在癌症中的作用  

Roles of homologous recombination repair protein Rad51 in cancer

作　　者：郑云峰 杨帆[2] 郭泽庚 ZHENG Yunfeng;YANG Fan;GUO Zegeng(Department of Gastric Surgery,Fujian Medical University Union Hospital,Fuzhou 350001,China;Department of Respiratory Medicine,Fujian Medical University Union Hospital,Fuzhou 350001,China;Key Laboratory of Gastrointestinal Malignancy of Ministry of Education,Fujian Medical University,Fuzhou 350108,China)

机构地区：[1]福建医科大学附属协和医院胃外科,福州350001 [2]福建医科大学附属协和医院呼吸内科,福州350001 [3]福建医科大学消化道恶性肿瘤教育部重点实验室,福州350108

出　　处：《生命的化学》2022年第10期1874-1880,共7页Chemistry of Life

基　　金：白求恩·肿瘤基础研究计划项目(X-J-2020-016)。

摘　　要：Rad51重组酶作为同源重组的核心因子,在DNA损伤修复过程中发挥着关键作用。Rad51在多种肿瘤组织中的表达异常增高,其功能失调与肿瘤的发生、进展、放疗抵抗及化疗耐药等密切相关。此外,Rad51基因多态性及表达变化会导致癌症风险增加,显著影响患者生存预后。有效下调Rad51基因表达、降低肿瘤同源重组修复能力、逆转肿瘤治疗耐受,具有潜在的临床价值。在此,本文将对Rad51的结构、功能及其在癌症治疗中的研究进展进行综述。As the core factor of homologous recombination, Rad51 recombinase plays an essential role in the process of DNA damage repair. Multiple studies have shown that the expression of Rad51 in various tumors is abnormally elevated, and its dysfunction is closely related to tumor occurrence, progression, radioresistance and chemotherapy resistance. In addition, polymorphisms and changes in the expression of Rad51 lead to increased cancer risk and significantly affect the survival and prognosis of patients. Effective downregulation of Rad51 gene expression, reduction of tumor homologous recombination repair ability, and reversal of tumor therapy resistance have potential clinical value. This paper will review the structure, function and research progress of Rad51 in cancer therapy.

关 键 词：RAD51 同源重组修复 DNA双链断裂 肿瘤 

分 类 号：R730.2[医药卫生—肿瘤]