探究胞二磷胆碱注射液联合抗血小板治疗急性脑梗死昏迷的临床应用效果  

Clinical Application Effect Exploration of Citicoline Injection Combined with Antiplatelet in Treatment of Coma Due to Acute Cerebral Infarction

作　　者：郑跃泽 吴连连 ZHENG Yueze;WU Lianlian(Rizhao City Donggang District Nanhu Central Hospital,Rizhao,Shandong,276817)

机构地区：[1]日照市东港区南湖中心卫生院,山东日照276817

出　　处：《智慧健康》2022年第30期111-115,133,共6页Smart Healthcare

摘　　要：目的分析临床中对急性脑梗死昏迷患者采取胞二磷胆碱注射液联合抗血小板治疗的效果。方法回顾性分析于2019年12月-2021年12月间于本院治疗的70例急性脑梗死昏迷患者进行研究,本研究经伦理委员会同意后进行,依据治疗方法的不同分成两组,一组为参考组,采取胞二磷胆碱注射液治疗,另一组为联合组,采取胞二磷胆碱注射液联合抗血小板治疗。记录并对比两组患者的治疗效果,以及美国国立卫生研究院卒中量表(NIHSS)和格拉斯哥昏迷评分(GCS),并检测对比治疗前后两组患者血小板参数(PLC、PAGTmax)、凝血-纤溶指标(D-D、FIB)水平。结果联合组患者总有效率(88.57%)高于参考组患者(77.14%),差异有统计学意义(P<0.05)。两组患者NIHSS和GCS评分治疗前对比无统计学意义(P>0.05);治疗后,两组患者NIHSS和GCS评分均优于治疗前,而联合组患者则更优于参考组患者,差异有统计学意义(P<0.05)。两组患者PLC、PAGTmax指标治疗前对比无统计学意义(P>0.05);治疗后,两组患者PLC、PAGTmax指标均优于治疗前,而联合组患者则更优于参考组患者,差异有统计学意义(P<0.05)。两组患者D-D、FIB指标治疗前对比无统计学意义(P>0.05);而治疗后,两组患者D-D、FIB指标优于治疗前,而联合组患者则更优于参考组患者,差异有统计学意义(P<0.05)。结论临床中急性脑梗死昏迷患者采取胞二磷胆碱注射液与抗血小板联合治疗的效果更好,并且能够有效的改善患者神经功能损伤,以及抑制血小板的活性,及时纠正患者的凝血-纤溶系统紊乱,有利于患者的预后恢复。Objective To analyze clinical effect of CDPC injection combined with antiplatelet therapy on comatose patients with acute cerebral infarction.Methods The paper reviewed and analyzed 70 cases coma patients with acute cerebral infarction treated in our hospital from December 2019 to December 2021.The study was carried out with the consent of the Ethics Committee.According to different treatment methods,they were divided into two groups:reference group was treated with CDPC injection,and combination group,treated with CDPC injection combined with antiplatelet therapy.Curative effect between two groups,as well as National Institutes of Health Stroke Scale(NIHSS)and Glasgow Coma Scale(GCS),were recorded and compared.Platelet parameters(PLC,PAGTmax),coagulation fibrinolysis index(D-D,FIB)levels between two groups before and after treatment were measured and compared.Results Total effective rate of combination group(88.57%)was significantly higher than reference group(77.14%)(P<0.05).There was no significant difference in NIHSS and GCS scores between two groups before treatment(P>0.05).After treatment,NIHSS and GCS scores of two groups were better than before,while those of combination group were better than reference group,with statistically significant difference(P<0.05).There was no significant difference in indexes of PLC and PAGTmax between two groups before treatment(P>0.05).After treatment,indexes of PLC and PAGTmax in two groups were better than before treatment,those in combination group were better than reference group,with statistically significant difference(P<0.05).There was no significant difference in D-D and FIB between two groups before treatment(P>0.05).After treatment,D-D and FIB indexes of two groups were better than before treatment,while those of combination group were better than reference group,with statistically significant difference(P<0.05).Conclusion In clinical practice,combined treatment of CDPC injection and antiplatelet can achieve good effect for coma patients due to acute cerebral infar

关 键 词：急性脑梗死 昏迷 阿司匹林 胞二磷胆碱注射液 

分 类 号：R743.3[医药卫生—神经病学与精神病学]