经动脉化疗栓塞治疗头颈部恶性肿瘤疗效初探  

Efficacy Analysis of Transarterial Chemoembolization in the Treatment of Head and Neck Malignant Tumors

作　　者：李臻[1] 谢炳灿 李鑫[1] 王丽萍[2] 张毅[3] 詹鹏超 王若愚[4] 张玉元 叶书文 余鹏 LI Zhen;XIE Bingcan;LI Xin(Department of Interventional Radiology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,Henan Province 450052,P.R.China)

机构地区：[1]郑州大学第一附属医院放射介入科,450052 [2]郑州大学第一附属医院肿瘤科,450052 [3]郑州大学第一附属医院生物治疗中心,450052 [4]郑州大学第一附属医院急诊科,450052

出　　处：《临床放射学杂志》2022年第9期1761-1765,共5页Journal of Clinical Radiology

摘　　要：目的 探讨经动脉化疗栓塞治疗头颈部恶性肿瘤的近期疗效及安全性方法 回顾性分析25例头颈部恶性肿瘤患者的临床资料,所有患者均经病理学确诊,其中经导管动脉栓塞术(TAE)7例,经导管动脉化疗栓塞术(TACE)18例。所有患者随访至2021年3月10日,随访终点为患者死亡。对比术前及术后1、3、6、12个月实验室及影像学检查评估近期疗效,根据术后有无并发症评估安全性。对随访结果进行统计学分析,记录总生存期(OS)及无进展生存期(PFS)。结果 25例患者共行介入治疗46次,平均(1.76±0.88)次;随访1~48个月,平均随访(26.80±4.77)个月。介入治疗后近期内患者症状、肿瘤负荷均有不同程度缓解,术后1、3、6、12个月的客观缓解率分别为84%(21/25)、76%(19/25)、40%(10/25)、28%(7/25),疾病控制率分别为100%(25/25)、88%(22/25)、64%(16/25)、32%(8/25)。术后皮肤破溃发生率为16%(4/25),无严重不良事件发生。中位OS为15个月[95%CI(13.25,16.75)],中位PFS 12个月[95%CI(6.33,17.67)]。结论 经动脉化疗栓塞治疗头颈部恶性肿瘤近期临床疗效确切,安全有效。Objective To investigate the short term efficacy and the safety of transarterial chemoembolization in the treatment of head and neck malignant tumors. Methods The clinical data of 25 patients with head and neck malignant tumor admitted to our department from October 2013 to February 2021 were retrospectively analyzed.All patients were pathologically confirmed, 7 patients underwent transcatheter arterial embolization(TAE),and 18 patients underwent Transcatheter arterial chemoembolization(TACE).All patients were followed up until March 10,2021,and the end point of follow up was death.Laboratory and imaging examinations were compared between preoperative and postoperative 1,3,6,and 12 months to evaluate the short term efficacy, and safety was assessed according to the presence of postoperative complications.Follow up results were statistically analyzed and overall survival(OS) and progression free survival(PFS) were recorded. Results A total of 46 times of interventional therapy were performed in 25 patients, with an average of(1.76±0.88) times.The patients were followed up for 1-48 months, with an average follow up of(26.80±4.77) months.After interventional therapy, the symptoms and tumor load of the patients were relieved to varying degrees in the near term.The ORR at 1,3,6 and 12 months were 84%(21/25),76%(19/25),40%(10/25) and 28%(7/25),respectively.DCR were 100%(25/25),88%(22/25),64%(16/25) and 32%(8/25),respectively.The incidence of postoperative skin ulceration was 16%(4/25),and no serious adverse events occurred.The median OS was 15 months [95%CI(13.25,16.75)]and the median PFS was 12 months[95%CI(6.33,17.67)]. Conclusion Transarterial chemoembolization is safe and effective in the treatment of head and neck malignant tumors.

关 键 词：头颈恶性肿瘤 化疗栓塞 介入治疗 

分 类 号：R739.91[医药卫生—肿瘤]