CEA、CA125、CA199及AFP联合检测对卵巢癌的诊断价值  

The Diagnostic Value of Combined Detection of CEA, CA125, CA199 and AFP in Ovarian Cancer

作　　者：曹文 CAO Wen(Department of Laboratory,Dandong Central Hospital,Dandong 118000,China)

机构地区：[1]丹东市中心医院检验科,辽宁丹东118000

出　　处：《中国医药指南》2023年第3期120-122,共3页Guide of China Medicine

摘　　要：目的 评价卵巢癌诊断中进行抗原199(carbohydrate antigen199,CA199)、糖链抗原125(carbohydrate antigen125,CA125)、癌胚抗原(carcinoembryonic antigen,CEA)、甲胎蛋白(alpha-fetoprotein,AFP)联合检测的价值,为卵巢癌疾病诊断工作提供参考,以尽早干预、促进患者预后。方法 选择我院2018年8月至2019年10月期间收治的卵巢癌、卵巢良性肿瘤患者,各选取80例,作为观察1组与观察2组。另外,选择同期80名健康体检者,作为对照组。经医院伦理委员会审核批准,参与者知情同意配合,观察1组、观察2组与对照组受检人群均进行CEA、CA125、CA199、AFP联合检测,对比3组受检人群的相应检测结果以及联合检测、单项检测阳性率情况。结果 3组受检人员组间CEA、CA125、CA199、AFP检测结果比较,观察1组卵巢癌患者的各项指标检测结果 CA199(78.30±33.20)U/m L、CA125(82.70±45.50)U/m L、CEA(12.25±5.05)μg/L、AFP(37.60±15.05)μg/L均明显高于观察2组和对照组,P<0.05。另外,观察1组卵巢癌患者联合检测阳性率明显高于CEA、CA125、CA199、AFP单一检测,P<0.05。结论 CA199、CA125、CEA、AFP联合检测敏感度较高,能够提高卵巢癌疾病诊断准确率,做到早发现、早治疗,从而提供卵巢癌疾病患者的预后,提供患者的生活与生存质量。Objective To evaluate the value of combined detection of antigen 199(CA199), carbohydrate antigen 125(CA125), carcinoembryonic antigen(CEA) and alpha fetoprotein(AFP) in the diagnosis of ovarian cancer, so as to provide reference for the diagnosis of ovarian cancer, and to intervene as early as possible and promote the prognosis of patients. Methods Selected patients with ovarian cancer and benign ovarian tumors admitted to our hospital from August 2018 to October 2019, 80 cases each were selected as observation group 1 and observation group 2. In addition,80 healthy subjects in the same period were selected as the control group. After review and approval by the hospital ethics committee, the participants informed and agreed to cooperate, the observation group 1, observation group 2 and the control group were all tested for CEA, CA125, CA199, and AFP,and the corresponding test results of the three groups were compared and combined the positive rate of tests and individual tests. Results The CEA,CA125, CA199, and AFP test results were compared among the three groups of subjects. The test results of various indicators in the observation group 1 of ovarian cancer patients were observed: CA199(78.30±33.20) U/mL, CA125(82.70±45.50) U/mL, CEA(12.25±5.05) μg/L, AFP(37.60±15.05) μg/L were significantly higher than the observation group 2 and the control group, P<0.05. In addition, the positive rate of combined detection of ovarian cancer patients in the observation group 1 was significantly higher than that of CEA, CA125, CA199, and AFP single detection, P<0.05. Conclusion The combined detection of CA199, CA125, CEA, and AFP has high sensitivity, which can improve the diagnostic accuracy of ovarian cancer, achieve early detection and early treatment, thereby providing the prognosis of patients with ovarian cancer and improving the quality of life and life of patients.

关 键 词：卵巢癌诊断 CEA CA125 CA199 AFP 检测阳性率 卵巢良性肿瘤 

分 类 号：R737.3[医药卫生—肿瘤]