溶栓胶囊对气虚血瘀型脑梗死患者脑血流动力学、神经及氧化应激的影响  

Effects of Plasmin Capsules on Cerebral Hemodynamics,Nerve and Oxidative Stress Protection in Patients with Cerebral Infarction for Qi Deficiency and Blood Stasis Type

作　　者：于红梅 缪亚秀 冯小飞 YU Hong-mei;MIAO Ya-xiu;FENG Xiao-fei(Department of Neurology,Haian Hospital of Traditional Chinese Medicine,Haian,Jiangsu 226600,China)

机构地区：[1]海安市中医院神经内科,江苏海安226600

出　　处：《临床误诊误治》2022年第12期98-102,共5页Clinical Misdiagnosis & Mistherapy

基　　金：南通市中医医疗联盟课题(TZYK202014);南通市科研计划项目(MSZ20086)。

摘　　要：目的探讨溶栓胶囊对气虚血瘀型脑梗死患者脑血流动力学、神经及氧化应激的影响。方法选取2017年1月—2022年6月收治的气虚血瘀型脑梗死104例,根据治疗方法不同将其分为试验组(52例)和对照组(52例)2组。试验组在常规康复治疗基础上给予溶栓胶囊治疗,对照组给予常规康复治疗。比较2组治疗4周后临床效果,治疗前及治疗4周后脑血流动力学指标、神经功能、生活活动能力及氧自由基。结果治疗前,2组脑血流动力学指标、神经功能评分、生活活动能力评分及氧自由基指标比较差异无统计学意义(P>0.05)。治疗4周后,试验组总有效率高于对照组;2组大脑平均血流速度(Vm)、Barthel指数评分及超氧化物歧化酶(SOD)均快于或高于治疗前,搏动指数(PI)、阻力指数(RI)、美国国立卫生研究院卒中量表(NIHSS)评分、过氧化脂质(PLO)、一氧化氮(NO)及丙二醛(MDA)均低于治疗前;试验组Vm、Barthel指数评分及SOD均快于或高于对照组,PI、RI、NIHSS评分、PLO、NO及MDA均低于对照组(P<0.05)。结论溶栓胶囊治疗气虚血瘀型脑梗死患者临床效果显著,可改善脑血流动力学指标、神经功能及生活活动能力,并能够清除氧自由基,减轻氧化应激损伤。Objective To investigate the effect of Rongshuan capsules on cerebral hemodynamics,nerve and oxidative stress in patients with cerebral infarction of Qi deficiency and blood stasis type.Methods A total of 104 patients with cerebral infarction of Qi deficiency and blood stasis type who were treated from January 2017 to June 2022 were selected,and they were divided into two groups according to different treatment methods:the experimental group(n=52)and the control group(n=52).The experimental group was given Rongshuan capsules on the basis of conventional rehabilitation therapy,while the control group was given conventional rehabilitation therapy.The clinical effect at 4 weeks after treatment,cerebral hemodynamic indexes,neurological function scores,activity of daily living(ADL)scores and oxygen free radical indexes before and at 4 weeks after treatment were compared between the two groups.Results Before treatment,there were no significant differences in cerebral hemodynamic indexes,neurological function scores,ADL scores and oxygen free radical indexes between the two groups(P>0.05).At 4 weeks after treatment,the total effective rate of the experimental group was higher than that of the control group;the mean blood flow velocity(Vm),Barthel index score and oxide dismutase(SOD)of the two groups were all faster or higher than those before treatment,and the resistance index(RI),pulsatility index(PI),National Institutes of Health Stroke Scale(NIHSS)score,lipid peroxide(LPO),nitric oxide(NO),and malondialdehyde(MDA)were all lower than those before treatment.Vm,Barthel index scores and SOD in the experimental group were faster or higher than those in the control group,while PI,RI,NIHSS scores,LPO,NO and MDA were all lower than those in the control group(P<0.05).Conclusion Rongshuan capsules has a significant clinical effect in the treatment of cerebral infarction patients with Qi deficiency and blood stasis type,which can improve cerebral hemodynamic indexes,neurological function and ADL,scavenge oxygen free radicals an

关 键 词：溶栓胶囊 气虚血瘀 脑梗死 血流动力学 神经功能 氧自由基 

分 类 号：R743.33[医药卫生—神经病学与精神病学]