血清雌激素检测在男性肺癌诊断中的价值分析  

Estrogen is an important biomarker to improve the diagnostic efficiency of male patients with lung cancer

作　　者：周啸 熊乐财 代鹏 唐和孝[1] ZHOU Xiao;XIONG Lecai;DAI Peng(Department of Thoracic Surgery,Zhongnan Hospital of Wuhan University,Wuhan,Hubei,430071,China)

机构地区：[1]武汉大学中南医院胸外科,430071

出　　处：《临床外科杂志》2022年第10期967-969,共3页Journal of Clinical Surgery

摘　　要：目的探讨血清雌激素(E2)在男性肺癌病人诊断中的临床价值。方法2019年1月~2021年8月我院就诊的肺部疾病病人141例,113例肺癌病人为观察组,28例肺良性病变病人为对照组,比较两组病人E2水平及及肺癌病人术前、术后E2水平变化,线性回归ROC工作特征曲线分析E2对肺癌的诊断效率及其与神经元特异性烯醇化酶、癌胚抗原、CA125联合检测的诊断效率。结果肺癌病人E2水平显著升高,且与TNM分期呈正相关(P<0.05)。分析术后E2水平变化发现,早期病人(Ⅰ~Ⅱ期和N0-N1期)术后大部分下降,而晚期病人(Ⅲ~Ⅳ和N2期)大部分呈现上升趋势。与常见肿瘤标志物单独检测比较,E2单独检测诊断敏感性和准确性最高。E2与癌胚抗原、糖类抗原CA125联合诊断显示出最佳的联合诊断效果(AUC=0.837)。结论血清E2是男性肺癌诊断的潜在标志物。Objective To investigate the clinical value of estrogen and combined detection with common lung cancer biomarkers in the diagnostic efficiency of male lung cancer patients.Methods This study included 141 male patients with lung disease who have tested the serum E2 level between January,2019 and May,2021.The serum levels of carcinoembryonic antigen(CEA),cancer antigen 125(CA125)and neuron specific enolase(NSE)were measured and statistically analyzed for comparing with estrogen.Results The study included 28 patients with benign lung lesions(BPL)and 113 patients with lung cancer.The results showed that the level of E2 in patients with lung cancer was significantly increased(P=0.0034)and positively correlated with TNM staging(P=0.0022).Patients with stageⅠ~Ⅱand N0-N1 showed a decline in E2 postoperatively,while most patients with stageⅢ~Ⅳand N2 showed an increase in E2 level after surgery.With BPL group as control,E2 showed the highest sensitivity and accuracy in the diagnosis of lung cancer compared with CEA,CA125 and NSE.Combined detection of E2,CEA and CA125 showed the best diagnostic ability(AUC=0.837).Conclusions Estrogen is a potential biomarker for the diagnosis of male lung cancer.

关 键 词：雌激素 肺癌 诊断 肿瘤标志物 

分 类 号：R734.2[医药卫生—肿瘤]