益气健脾法联合化疗治疗结直肠癌术后疗效及安全性的Meta分析  

A Meta-analysis of efficacy and safety of the Yiqi Jianpi method plus chemotherapy on postoperative colorectal cancer

作　　者：张继康 邱晓雯 金振华 徐晋[2] ZHANG Jikang

机构地区：[1]南京中医药大学,江苏南京210029 [2]南京中医药大学第二附属医院,江苏南京210017

出　　处：《中医临床研究》2022年第31期53-58,共6页Clinical Journal Of Chinese Medicine

摘　　要：目的:通过Meta分析方法评价益气健脾法联合化疗治疗结直肠癌术后的疗效及安全性。方法:计算机检索中国期刊文献数据库、万方数据库、维普数据库、中国生物医学文献数据库、PubMed、Cochrane Library、Web of Science、EMBASE查找益气健脾法联合化疗治疗结直肠癌术后的随机对照试验研究。由两名研究者独立对纳入研究进行资料提取和方法学质量评价,应用RevMan 5.3进行统计分析。结果:共纳入17项随机对照试验,共1281例受试者。Meta分析结果显示:与单纯化疗相比,益气健脾法联合化疗可以显著提高生活质量(P<0.00001),提高中医证候疗效(P<0.00001),增加CD3^(+)、CD4^(+)/CD8^(+)值(P<0.00001),减少红细胞下降(P=0.04)、血小板下降(P=0.05)、恶心呕吐(P<0.0001)、腹泻(P<0.01)、肝肾功能损害(P=0.005,P=0.04)及神经毒性(P=0.0001)等不良反应。两种治疗方法在提高CD4^(+)、NK细胞计数,降低CD8^(+)水平,减少白细胞下降方面无明显优势,差异无统计学意义(P>0.05)。结论:益气健脾法联合化疗治疗结直肠癌术后对比单纯化疗有显著优势,但还需要纳入大样本、高质量的研究文献,以提供更可靠的证据和支撑。Objective:To evaluate the efficacy and safety of the Yiqi Jianpi method(益气健脾法)plus chemotherapy on colorectal cancer by a meta-analysis.Methods:In CNKI,Wanfang,VIP,CBM,PubMed,Cochrane Library,Web of Science and EMBASE,the studies on randomized controlled trails of the Yiqi Jianpi method plus chemotherapy in the treatment of colorectal cancer were retrieved by computer.Two researchers independently conducted data extraction and methodological quality evaluation for the included studies,and a statistical analysis was conducted by RevMan 5.3 software.Results:A total of 17 randomized controlled trials were included finally,including 1281 subjects.The results of the meta-analysis showed that compared with simple chemotherapy,the Yiqi Jianpi method plus chemotherapy could significantly improve the quality of life(P<0.00001),improve the curative effect of TCM syndromes(P<0.00001),increase the count of CD3^(+)cells,and CD4^(+)/CD8^(+)ratio(P<0.00001),prevent the decline of red blood cells(P=0.04)and platelets(P=0.05),and reduce the occurrence of adverse reactions such as nausea and vomiting(P<0.0001),diarrhea(P<0.01),liver and kidney function damage(P=0.005,P=0.04),and neurotoxicity(P=0.0001).There was no significant difference between the two treatment methods in increasing CD4^(+)level and NK cell counts,reducing CD8^(+)level,and preventing white blood cell decline(P>0.05).Conclusion:The Yiqi Jianpi method plus chemotherapy shows significant advantages over chemotherapy alone in the treatment of postoperative colorectal cancer,but it is necessary to include large samples and high-quality research literature in order to provide more reliable evidence and support.

关 键 词：益气健脾法 结直肠癌 安全性 META分析 

分 类 号：R735.35[医药卫生—肿瘤]