Reading-related Brain Function Restored to Normal After Articulation Training in Patients with Cleft Lip and Palate:An fMRI Study  

作　　者：Liwei Sun Wenjing Zhang Mengyue Wang Songjian Wang Zhen Li Cui Zhao Meng Lin Qian Si Xia Li Ying Liang Jing Wei Xu Zhang Renji Chen Chunlin Li 

机构地区：[1]School of Biomedical Engineering,Capital Medical University,Beijing,100069,China [2]Beijing Advanced Innovation Center for Big Data-Based Precision Medicine,Capital Medical University,Beijing,100069,China [3]Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application,School of Biomedical Engineering,Capital Medical University,Beijing,100069,China [4]Beijing Stomatological Hospital,Capital Medical University,Beijing,100050,China [5]School of Life Science,Beijing Institute of Technology,Beijing,100081,China [6]Beijing Institute of Otolaryngology-Head and Neck Surgery,Beijing,100005,China [7]Key Laboratory of Otolaryngology-Head and Neck Surgery(Capital Medical University),Ministry of Education,Beijing,100005,China [8]Beijing Tongren Hospital,Capital Medical University,Beijing,100005,China [9]Department of Ultrasound,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing,100026,China [10]Peking University First Hospital,Beijing,100034,China

出　　处：《Neuroscience Bulletin》2022年第10期1215-1228,共14页神经科学通报（英文版）

基　　金：We are grateful to all the patients and healthy controls for their generous participation in this study.This work was supported by grants from the National Natural Science Foundation of China(81771909,61701323,and 62171300);the Discipline Construction Foundation of Beijing Stomatological Hospital(19-09-24);the Capital Medical University Research and Development Fund(PYZ19081);Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(XML201714).

摘　　要：Cleft lip and/or palate(CLP)are the most common craniofacial malformations in humans.Speech problems often persist even after cleft repair,such that follow-up articulation training is usually required.However,the neural mechanism behind effective articulation training remains largely unknown.We used fMRI to investigate the differences in brain activation,functional connectivity,and effective connectivity across CLP patients with and without articulation training and matched normal participants.We found that training promoted task-related brain activation among the articulation-related brain networks,as well as the global attributes and nodal efficiency in the functional-connectivity-based graph of the network.Our results reveal the neural correlates of effective articulation training in CLP patients,and this could contribute to the future improvement of the post-repair articulation training program.

关 键 词：Non-syndromic cleft lip and palate Articulation training FMRI Functional connectivity Graph-based network analysis 

分 类 号：R741[医药卫生—神经病学与精神病学]