Molecular biomarkers for gestational diabetes mellitus and postpartum diabetes  

作　　者：Wenqian Lu Cheng Hu 

机构地区：[1]Shanghai Diabetes Insttute,Shanghai Jiao Tong University Afiliated Sixth People's Hospital,Shanghai 200233,China [2]The Third School of Clinical Medicine,Southern Medical University,Guangzhou,Guangdong 510630,China [3]Department of Endocrinology and Metabolism,Fengxian Central Hospital Affliated to the Southern Medical University,Shanghai 201400,China

出　　处：《Chinese Medical Journal》2022年第16期1940-1951,共12页中华医学杂志（英文版）

摘　　要：Gestational diabetes mellitus(GDM)is a growing public health problem worldwide that threatens both maternal and fetal health.Identifying individuals at high risk for GDM and diabetes after GDM is particularly useful for early intervention and prevention of disease progression.In the last decades,a number of studies have used metabolomics,genomics,and proteomic approaches to investigate associations between biomolecules and GDM progression.These studies clearly demonstrate that various biomarkers reflect pathological changes in GDM.The established markers have potential use as screening and diagnostic tools in GDM and in postpartum diabetes research.In the present review,we summarize recent studies of metabolites,single-nucleotide polymorphisms,microRNAs,and proteins associated with GDM and its transition to postpartum diabetes,with a focus on their predictive value in screeningand diagnosis.

关 键 词：Gestational diabetes mellitus Biomarkers Metabolomics PROTEOMICS MICRORNA Single-nucleotide polymorphism 

分 类 号：R714.256[医药卫生—妇产科学]