Hyaluronic acid-methacrylic anhydride/polyhexamethylene biguanide hybrid hydrogel with antibacterial and proangiogenic functions for diabetic wound repair  

作　　者：Yike Li Huiyu Zheng Yaxian Liang Ming Xuan Guiting Liu Huixu Xie 

机构地区：[1]State Key Laboratory of Oral Diseases,National Clinical Research Center for Oral Diseases,West China Hospital of Stomatology,State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610041,China

出　　处：《Chinese Chemical Letters》2022年第12期5030-5034,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.52103039);Medical Science and Technology Project of Sichuan Provincial Health Commission(No.21PJ059);Science and Technology Application Fundamental Project of Sichuan Province(No.2019YJ0724);Sichuan University Postdoctoral Interdisciplinary Innovation Fund.

摘　　要：Diabetic wounds lead to a decrease in quality of life and an increase in mortality.Current treatment strategies include preventing bacterial adhesion while improving microcirculation.As a new type of wound dressing that imitates natural skin,hydrogel has gradually emerged with its excellent properties.However,existing hydrogels rarely achieve satisfactory results in promoting wound repair and antibacterial simultaneously.In this case,we prepared methacrylic anhydride chemically modified hyaluronic acid as a hydrogel matrix,added polyhexamethylene biguanide as an antibacterial component,and loaded sodium alginate/salidroside composite microspheres which could sustainably release salidroside and thus promote angiogenesis.Hybrid hydrogel(HAMA/PHMB-Ms)was synthesized via photocrosslinking,and its chemical structure,particle size distribution and microstructure were characterized.The satisfactory antibacterial properties of the HAMA/PHMB(15%)-Ms hydrogel were studied in vitro,and its antibacterial rates against E.coli and S.aureus were 97.85%and 98.56%,respectively.In addition,after demonstrating its good biocompatibility,we verified that the HAMA/PHMB-Ms hydrogel has increased granulation tissue formation,more collagen deposition,more subcutaneous capillary formation,and better wound healing than blank control,HAMA and HAMA/PHMB hydrogel on the back wound model of diabetic mice.The results confirmed that HAMA/PHMB-Ms hydrogel was a promising material for the treatment of the diabetic wounds.

关 键 词：HYDROGEL Diabetic wounds ANTIBACTERIAL ANGIOGENESIS 

分 类 号：R318.08[医药卫生—生物医学工程] TQ427.26[医药卫生—基础医学]