Rhodium catalyzed asymmetric synthesis of Chiraphos derivatives  

作　　者：Ying-Ying Sun Bin Zhang Liangbin Yu Ranran Cui Qingyang Zhao Qing-Wei Zhang 

机构地区：[1]Department of Chemistry,University of Science and Technology of China,Heifei 230026,China [2]School of Pharmaceutical Sciences(Shenzhen),Shenzhen Campus of Sun Yat-sen University,Shenzhen 518107,China

出　　处：《Chinese Chemical Letters》2022年第12期5084-5087,共4页中国化学快报（英文版）

基　　金：support from the National Natural Science Foundation of China (Nos. 21901235 and 22071224);the USTC Research Funds of the Double First-Class Initiative (No. YD20600002010);the Anhui Provincial Natural Science-Foundation (No. 1908085MB34);the Science, Technology and Innovation Commission of Shenzhen (No. JCYJ20190807155201669)

摘　　要：Herein,we report a highly efficient versatile synthetic route to Chiraphos derivatives through Rh/Ph-bod catalyzed asymmetric addition of aryl boronic acids to phosphinyl dienes.Various substituted phosphinyl dienes,both on the parent skeleton and the phosphine atoms,were well tolerated with this method and provided chiral phosphine oxides in satisfied yield and up to 95%ee.The corresponding Chiraphos derivative displayed an advantage over Chiraphos in the representative Pd-catalyzed asymmetric 1,4-addition reaction.

关 键 词：RHODIUM PHOSPHINE Diene ligand 1 4-Addition Chiraphos 

分 类 号：O621.251[理学—有机化学]