血清胃泌素、胃动素、瘦素在食管癌支架置入术后继发胃食管反流患者中的表达及其意义  

Expression and Significance of Serum Gastrin,Motilin and Leptin in Patients with Gastroesophageal Reflux after Esophageal Cancer Stent Implantation

作　　者：酒梦娜 张怡 JIU Meng-na;ZHANG Yi(Department of Gastroenterology,Ankang Central Hospital,Ankang Shaanxi 725000)

机构地区：[1]安康市中心医院,陕西安康725000

出　　处：《医学临床研究》2022年第11期1662-1665,共4页Journal of Clinical Research

摘　　要：【目的】探讨血清胃泌素(GAS)、胃动素(MTL)、瘦素(LEP)在食管癌支架置入术后继发胃食管反流患者中的表达及其意义。【方法】回顾性分析2019年1月至2022年1月本院收治的接受支架置入术治疗的214例食管癌患者的临床资料,根据术后是否发生胃食管反流将其分为胃食管反流组(n=78)和非胃食管反流组(n=136)。统计患者血清GAS、MTL、LEP等一般资料,分析术后胃食管反流发生情况,采用单因素及多因素Logistic回归分析食管癌支架置入术后继发胃食管反流的危险因素。【结果】两组患者高脂血症病史、低半坐卧位睡姿、高糖高脂饮食、常饮浓茶、适量运动、服用非甾体抗炎药、便秘及血清GAS、MTL、LEP水平比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析显示,高脂血症、高糖高脂饮食、常饮浓茶、服用非甾体抗炎药、便秘及术前GAS<108.00 pg/mL、术前MTL<213.28 pg/mL、术前LEP≥15.24 ng/mL是食管癌支架置入术后继发胃食管反流的独立危险因素(P<0.05),低半坐卧位睡姿、适量运动是术后继发胃食管反流的独立保护因素(P<0.05)。【结论】血清GAS、MTL、LEP与食管癌支架置入术后继发胃食管反流密切相关,血清GAS、MTL异常降低和血清LEP异常升高是食管癌支架置入术后继发胃食管反流的独立高危因素。【Objective】To investigate the expression and significance of serum gastrin(GAS),motilin(MTL)and leptin(LEP)in patients with gastroesophageal reflux after esophageal cancer stent implantation.【Methods】The clinical data of 214 patients with esophageal cancer who received stent implantation in our hospital from January 2019 to January 2022 were analyzed retrospectively.General data such as serum GAS,MTL and LEP were collected to analyze the occurrence of postoperative gastroesophageal reflux.Single factor and multi factor logistic regression were used to analyze the risk factors of secondary gastroesophageal reflux after esophageal cancer stent implantation.【Results】Gastroesophageal reflux after esophageal cancer stent implantation was significantly correlated with hyperlipidemia history,low semi sitting position,high sugar and high fat diet,regular drinking of strong tea,moderate exercise,taking NSAIDs,constipation and serum GAS,MTL,LEP(P<0.05).The history of hyperlipidemia,high sugar and high-fat diet,regular drinking of strong tea,taking NSAIDs,constipation,preoperative GAS<108.00 pg/mL,preoperative MTL<213.28 pg/mL,and preoperative LEP≥15.24 ng/mL were independent risk factors for gastroesophageal reflux after esophageal cancer stent implantation(P<0.05);Sleeping posture in low semi sitting position and proper exercise were independent protective factors for postoperative gastroesophageal reflux(P<0.05).【Conclusion】The serum GAS,MTL and LEP are closely related to the secondary gastroesophageal reflux after esophageal cancer stent implantation.The abnormal decrease of serum GAS,MTL and the abnormal increase of serum LEP are independent risk factors for the secondary gastroesophageal reflux after esophageal cancer stent implantation,which is worthy of clinical verification.

关 键 词：食管肿瘤/外科学 胃食管反流 支架 胃泌素类/血液 促胃动素/血液 瘦素/血液 

分 类 号：R735.1[医药卫生—肿瘤]