角蛋白7和p53蛋白与膀胱癌临床病理的相关性及预测复发风险的价值  

Relationship of Keratin 7 and P53 Protein with Clinicopathological Diagnosis and Recurrence Risk of Bladder Cancer

作　　者：方新颜[1] 顾颖慧 施艳琳[1] FANG Xin-yan;GU Ying-hui;SHI Yan-lin(Department of Pathology,Qidong Hospital of Traditional Chinese Medicine,Qidong Jiangsu 226200)

机构地区：[1]江苏省启东市中医院病理科,江苏启东226200

出　　处：《医学临床研究》2022年第11期1694-1697,共4页Journal of Clinical Research

摘　　要：【目的】探讨角蛋白7(KRT7)和p53蛋白与膀胱癌临床病理的相关性及其在复发风险预测中的价值。【方法】采用免疫组织化学染色法测定72例膀胱癌患者手术后癌组织与癌旁正常组织标本中KRT7、p53蛋白的表达情况,比较癌组织和癌旁组织中KRT7、p53蛋白阳性检出率,对比不同临床病理特征患者癌组织中KRT7、p53蛋白阳性检出率,观察KRT7、p53蛋白不同表达膀胱癌患者的3年复发情况。【结果】癌组织KRT7阳性检出率显著低于癌旁组织,p53蛋白阳性检出率显著高于癌旁组织,且差异有统计学意义(P<0.05);有被膜浸润、中低分化、淋巴结转移患者KRT7阴性检出率较高,p53蛋白阳性检出率较高,且差异有统计学意义(P<0.05);KRT7阴性、p53蛋白阳性膀胱癌患者3年复发率分别为46.15%、50.00%,均高于KRT7阳性、p53蛋白阴性患者的12.12%、15.00%,且差异均有统计学意义(Log-Rank=17.553、12.281,P<0.05)。【结论】膀胱癌患者癌组织中p53蛋白呈高表达,KRT7呈低表达,其表达水平与组织分化程度、淋巴结转移以及被膜浸润密切相关。【Objective】To investigate the correlation of keratin 7(KRT7)and p53 protein with clinicopathological features and recurrence prediction of bladder cancer.【Methods】The clinical data of 72 patients with bladder cancer in our hospital were retrospectively analyzed.The expression of KRT7 and p53 protein was measured by immunohistochemical staining,The positive rates of KRT7 and p53 protein in cancer tissues and adjacent tissues were compared between the two groups.The positive rates of KRT7 and p53 protein in different clinical and pathological characteristics were compared as well.The recurrence rate of 3 cases of bladder cancer patients with different expressions of KRT7 and p53 protein was observed.【Results】The positive rate of KRT7 in cancer tissues was significantly lower than that in adjacent tissues,while the positive rate of p53 protein was significantly higher than that in adjacent tissues(P<0.05).The negative detection rate of KRT7 and the positive detection rate of p53 protein were significantly higher in patients with capsule infiltration,medium-poor differentiation and lymph node metastasis(P<0.05).The 3-year recurrence rates of patients with KRT7 negative and p53 positive bladder cancer were 46.15%and 50.00%,respectively,which were higher than those of KRT7 positive and p53 negative patients.The recurrence rate was 12.12%and 15.00%,the difference was statistically significant(Log-Rank=17.553,12.281,P<0.05).【Conclusion】p53 protein was highly expressed in bladder cancer tissues,while KRT7 was lowly expressed.The expression level was closely related to histological differentiation,lymph node metastasis and infiltration of membrane.

关 键 词：膀胱肿瘤/病理学 角蛋白7 肿瘤抑制蛋白质P53 复发 

分 类 号：R737.140.4[医药卫生—肿瘤]