肺孤立性结节样腺癌PET/CT表现与丙酮酸激酶M2、硒结合蛋白-1表达的相关性  

Correlations of PET/CT findings,expression of pyruvate kinase M2 and selenium binding protein 1 of pulmonary solitary nodular adenocarcinoma

作　　者：赵佳佳 邢媛媛[1] 张欣[1] 贾丽美[1] 杨杰[1] ZHAO Jiajia;XING Yuanyuan;ZHANG Xin;JIA Limei;YANG Jie(Department of Nuclear Medicine,Affiliated Hospital of Chengde Medical College,Chengde 067000,China)

机构地区：[1]承德医学院附属医院核医学科,河北承德067000

出　　处：《中国医学影像技术》2022年第12期1838-1842,共5页Chinese Journal of Medical Imaging Technology

基　　金：2021年承德市科学技术研究与发展计划项目(202109A054)。

摘　　要：目的观察肺孤立性结节样腺癌PET/CT表现与丙酮酸激酶M2(PKM2)、硒结合蛋白-1(SBP-1)表达的相关性。方法以101例肺孤立性结节样腺癌为观察组,以68例肺良性肿瘤为对照组;比较2组病灶PKM2、SBP-1表达及PET/CT最大标准摄取值(SUV_(max))、峰值标准摄取值(SUV_(peak))和肿瘤代谢体积(MTV),分析观察组病灶PET/CT表现与PKM2、SBP-1表达的关系。结果观察组病灶PKM2高表达率高于(P<0.001)、SBP-1高表达率低于对照组(P<0.001);观察组病灶SUV_(max)、SUV_(peak)及MTV均高于对照组(P均<0.05)。观察组内PKM2高表达结节呈分叶状、多边形/不规则形、胸膜凹陷征占比及其SUV_(max)、SUV_(peak)和MTV均高于PKM2低表达结节(P均<0.05);SBP-1高表达结节呈分叶状、胸膜凹陷征占比及其SUV_(max)、SUV_(peak)和MTV均低于SBP-1低表达结节(P均<0.05)。观察组病灶呈分叶状、出现胸膜凹陷征、SUV_(max)、SUV_(peak)及MTV均与其PKM2表达呈正相关、与SBP-1表达呈负相关(P均<0.05)。结论肺孤立性结节样腺癌PET/CT表现与其PKM2及SBP-1表达相关。Objective To observe the correlations of PET/CT findings,expression of pyruvate kinase M2(PKM2)and selenium binding protein 1(SBP-1)of pulmonary solitary nodular adenocarcinoma.Methods A total of 101 patients with pulmonary solitary nodular adenocarcinoma(study group)and 68 patients with benign lung tumors(control group)were enrolled.The expression of PKM2 and SBP-1,the_(max)imum standard uptake value(SUV_(max)),peak standard uptake value(SUV_(peak))and metabolic tumor volume(MTV)of lesions were compared between groups.The correlations of PET/CT manifestations,the expression of PKM2 and SBP-1 of lesions in study group were analyzed.Results High expression rate of PKM2 of lesions in study group was higher(P<0.001),while of SBP-1 was lower than those in control group(P<0.001).SUV_(max),SUV_(peak)and MTV of lesions in study group were all higher than those in control group(all P<0.05).In study group,the percentage of lobar sign,polygonal/irregular shape and pleural depression sign,as well as SUV_(max),SUV_(peak)and MTV of nodules with high PKM2 expression were higher than those of nodules with low PKM2 expression(all P<0.05),while the percentage of lobar sign and pleural depression sign,as well as SUV_(max),SUV_(peak)and MTV of nodules with high SBP-1 expression were lower than those of nodules with low SBP-1 expression(all P<0.05).The lobar sign,pleural depression sign,SUV_(max),SUV_(peak)and MTV of lesions in study group were positively correlated with PKM2 expression but negatively correlated with SBP-1 expression(all P<0.05).Conclusion PET/CT findings of pulmonary solitary nodular adenocarcinoma were correlated with the expression of PKM2 and SBP-1.

关 键 词：肺腺癌 丙酮酸激酶 硒结合蛋白质类 正电子发射断层显像 体层摄影术 X线计算机 

分 类 号：R734.2[医药卫生—肿瘤] R817.4[医药卫生—临床医学]