内生场热疗联合肝脾双介入治疗中晚期肝癌的临床观察  

Clinical observation of endogenetic field hyperthermia combined with liver and spleen dual interventional therapy for moderate or advanced liver cancer

作　　者：郭双 龙光峰 黄东彬 管静 姚金娥 GUO Shuang;LONG Guang-feng;HUANG Dong-bin(Department of Oncology,Jiangmen People's Hospital,Jiangmen 529000,China)

机构地区：[1]广东省江门市人民医院肿瘤科,529000

出　　处：《中国现代药物应用》2022年第24期7-11,共5页Chinese Journal of Modern Drug Application

基　　金：江门市科技计划项目(项目编号:2020020100840002912);江门市科技计划项目(项目编号:2021YL02002)。

摘　　要：目的研究内生场热疗联合肝脾双介入治疗中晚期肝癌的临床效果。方法40例中晚期肝癌患者,通过计算机随机分组法分为对照组及观察组,每组20例。对照组采用单纯肝动脉化疗栓塞术治疗,观察组实施内生场热疗联合肝脾双介入治疗。比较两组患者临床疗效、生存情况[无进展生存期(PFS)、6个月生存率]、肝纤四项指标[血清透明质酸(HA)、层粘连蛋白(LN)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)]、卡氏(KPS)评分、不良反应及并发症发生情况。结果观察组的客观缓解率(ORR)为65.00%,与对照组的40.00%比较,差异无统计学意义(P>0.05);观察组的疾病总控制率90.00%高于对照组的55.00%,差异具有统计学意义(P<0.05)。治疗后,两组患者的HA、LN、PCⅢ、Ⅳ-C水平均低于本组治疗前,且观察组的HA、LN、PCⅢ、Ⅳ-C水平分别为(74.65±10.03)ng/ml、(65.84±7.26)ng/ml、(79.90±10.01)μg/L、(78.63±9.34)μg/L,均低于对照组的(103.37±20.16)ng/ml、(93.20±11.53)ng/ml、(110.84±14.36)μg/L、(111.18±13.62)μg/L,差异具有统计学意义(P<0.05)。两组恶心呕吐、腹胀、白细胞下降、发热、肝功能改变及肝区疼痛发生率比较,差异无统计学意义(P>0.05)。治疗后,两组患者的KPS评分均高于本组治疗前,且观察组患者的KPS评分(80.55±6.30)分高于对照组的(74.02±5.19)分,差异具有统计学意义(P<0.05)。观察组的PFS(4.48±0.79)个月长于对照组的(3.85±0.45)个月,6个月生存率90.00%高于对照组的60.00%,差异具有统计学意义(P<0.05)。结论对中晚期肝癌患者实施内生场热疗联合肝脾双介入治疗安全有效,可提升生存率且有利于肝纤维化、生存质量的改善。Objective To study the clinical effect of endogenetic field hyperthermia combined with liver and spleen dual interventional therapy for moderate or advanced liver cancer.Methods A total of 40 patients with moderate or advanced liver cancer were divided into control group and observation group according to computer random grouping method,with 20 cases in each group.The control group was treated by transcatheter hepatic arterial chemoembolization,and the observation group was treated by endogenetic field hyperthermia combined with liver and spleen dual interventional therapy.Both groups were compared in terms of clinical efficacy,survival status[progression free survival(PFS),6-month survival rate],four indexes of liver fiber[serum hyaluronic acid(HA),laminin(LN),procollagenⅢ(PCⅢ),collagenⅣ(Ⅳ-C)]and Karnofsky performance status(KPS)score and occurrence of complications.Results The objective response rate(ORR)of the observation group was 65.00%,which had no statistically significant difference compared with 40.00%of the control group(P>0.05).The total disease control rate in the observation group was 90.00%,which was higher than 55.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of HA,LN,PCⅢandⅣ-C in both groups were lower than those before treatment in this group;the levels of HA,LN,PCⅢandⅣ-C in the observation group were(74.65±10.03)ng/ml,(65.84±7.26)ng/ml,(79.90±10.01)μg/L and(78.63±9.34)μg/L,which were lower than(103.37±20.16)ng/ml,(93.20±11.53)ng/ml,(110.84±14.36)μg/L and(111.18±13.62)μg/L in the control group;the differences were statistically significant(P<0.05).There was no statistically significant difference in the incidence of nausea and vomiting,abdominal distension,leukocytopenia,fever,liver function changes and liver pain between the two groups(P>0.05).After treatment,the KPS scores of patients in both groups were higher than those before treatment in this group,and the KPS score(80.55±6.30)points in the observatio

关 键 词：中晚期肝癌 内生场热疗 肝脾双介入 

分 类 号：R735.7[医药卫生—肿瘤]