用于早期癌症诊断的尿液挥发性有机化合物的体外检测技术研究进展  

Research progress in in vitro detection of urinary volatile organic compounds for early cancer diagnosis

作　　者：丁园 张文宇 孙宇帆 黄志健 韩雨彤 朱志刚 Ding Yuan;Zhang Wenyu;Sun Yufan;Huang Zhijian;Han Yutong;Zhu Zhigang(School of Health and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093

出　　处：《国际生物医学工程杂志》2022年第2期176-185,共10页International Journal of Biomedical Engineering

基　　金：上海市科委高校能力建设项目(21010502800)。

摘　　要：随着全球癌症负担的进一步增加,各种疾病日益挑战着人类的健康状况和生活质量,因此癌症的早期筛查至关重要。尿液挥发性有机化合物(VOCs)检测具有样品易获得、患者接受程度高、无创等优点受到研究者的青睐和关注。主要对现有基于尿液VOCs进行癌症诊断的技术方法进行总结,并综述了对相关癌症诊断的一些研究,最后对存在的障碍和未来展望进行了深入思考和探讨。通过介绍尿液VOCs的一些前沿检测技术,以期为这一跨医学、材料学等多学科领域的研究者对于尿液VOCs检测提供参考。With the further increase of the global cancer burden,various cancers are increasingly challenging human health status and quality of life.Thus,early screening of cancer is crucial.Urinary volatile organic compounds(VOCs)detection techniques have the advantages of easy access to samples,high acceptance of patients,non-invasive,and so on,which have been favored and concerned by researchers.In this paper,existing techniques and methods for cancer diagnosis based on urine VOCs were described,relevant studies on the use of urine VOCs for cancer diagnosis were reviewed,and the barriers and future perspectives of the technique were discussed.This paper can be a reference for researchers working in the direction of urinary VOCs detection,a multidisciplinary field that spans medicine and materials science.

关 键 词：尿液 挥发性有机化合物 体外检测技术 癌症诊断 

分 类 号：R730.4[医药卫生—肿瘤]