Cooperative coordination-mediated multi-component self-assembly of“all-in-one”nanospike theranostic nano-platform for MRI-guided synergistic therapy against breast cancer  

作　　者：Xiaojie Chen Xudong Fan Yue Zhang Yinghui Wei Hangsheng Zheng Dandan Bao Hengwu Xu Ji-Gang Piao Fanzhu Li Hongyue Zheng 

机构地区：[1]School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China [2]Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province,School of Pharmaceutical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China [3]Libraries of Zhejiang Chinese Medical University,Zhejiang Chinese Medical University,Hangzhou 310053,China [4]Department of Dermatology&Cosmetology,The First Affiliated Hospital of Zhejiang Chinese Medical University(Zhejiang Provincial Hospital of Traditional Chinese Medicine),Hangzhou 310006,China [5]Academy of Chinese Medical Sciences,Zhejiang Chinese Medical University,Hangzhou 310053,China [6]Department of Pharmacy,Jinhua People's Hospital,Jinhua 321000,China

出　　处：《Acta Pharmaceutica Sinica B》2022年第9期3710-3725,共16页药学学报（英文版）

基　　金：supported by National Natural Science Foundation of China (81873014, 82074027, 81873018 and 82104405);Natural Science Foundation of Zhejiang Province (LZ21H280001 and LY21H280007, China);Zhejiang Chinese Medical University School-level Scientific Research Fund Project (2020ZG21, 2019ZG37, China);Traditional Chinese Medicine Science and Technology Plan of Zhejiang Province (2021ZQ036, China);Jinhua Science and Technology Research Plan Project (2019-4037, China)

摘　　要：Carrier-free multi-component self-assembled nano-systems have attracted widespread attention owing to their easy preparation,high drug-loading efficiency,and excellent therapeutic efficacy.Herein,MnAs-ICG nanospike was generated by self-assembly of indocyanine green(ICG),manganese ions(Mn^(2+)),and arsenate(AsO_(4)^(3−))based on electrostatic and coordination interactions,effectively integrating the bimodal imaging ability of magnetic resonance imaging(MRI)and fluorescence(FL)imaging-guided synergistic therapy of photothermal/chemo/chemodynamic therapy within an“all-in-one”theranostic nano-platform.The as-prepared MnAs-ICG nanospike had a uniform size,well-defined nanospike morphology,and impressive loading capacities.The MnAs-ICG nanospike exhibited sensitive responsiveness to the acidic tumor microenvironment with morphological transformation and dimensional variability,enabling deep penetration into tumor tissue and on-demand release of functional therapeutic components.In vitro and in vivo results revealed that MnAs-ICG nanospike showed synergistic tumor-killing effect,prolonged blood circulation and increased tumor accumulation compared to their individual components,effectively resulting in synergistic therapy of photothermal/chemo/chemodynamic therapy with excellent anti-tumor effect.Taken together,this new strategy might hold great promise for rationally engineering multifunctional theranostic nano-platforms for breast cancer treatment.

关 键 词：Carrier-free nanodrugs SELF-ASSEMBLY Nanospike Magnetic resonance imaging Tumor microenvironment-responsive Deep penetration Synergistic therapy Breast cancer 

分 类 号：R737.9[医药卫生—肿瘤]