血清微量元素与单患自闭症及共病性自闭症关系研究  

Study on the relationship between serum trace elements and single autism and comorbid autistic spectrum disorder

作　　者：毛丽萍 吴寿军 卢爱兰[3] 柴建峰 MAO Li-ping;WU Shou-jun;LU Ai-lan;CAI Jian-feng(Department of Rehabilitation,People’s Hospital of Pujiang,Pujiang,Zhejiang 322200,China;不详)

机构地区：[1]浦江县人民医院康复科,浙江浦江322200 [2]浦江县人民医院检验科,浙江浦江322200 [3]金华市中心医院康复科,浙江金华321000

出　　处：《中国卫生检验杂志》2022年第20期2532-2535,共4页Chinese Journal of Health Laboratory Technology

摘　　要：目的研究血清微量元素在单患自闭症和共病性自闭症患儿中的变化情况,以期为临床干预提供参考。方法选取2019年—2021年金华市单患自闭症儿童52例,多动症和自闭症共病性儿童52例,对应健康体检组儿童104例,检测3组儿童的血铁、锌、铜、铅、镁和钙含量进行比较。结果自闭症组和共病组血清微量元素水平检测结果差于对照组,其中血锌、铜和铅含量变化比较明显,自闭症组患者血铁、锌、铜、铅和钙的异常率显著高于对照组,差异有统计学意义(P<0.05),自闭症组与共病组血铅水平异常率差异有统计学意义(P<0.05)。结论血锌、铜和铅含量变化可能是导致儿童患自闭症的重要因素之一,并且随着血铅异常水平的升高,将会增加自闭症儿童同时增加患多动症等共病性疾病的风险。Objective To study the changes of serum trace elements in children with autistic spectrum disorder(ASD)alone and comorbid ASD,in order to provide reference for clinical intervention.Methods From 2019 to 2021,52 children with ASD alone(ASD group),52 children with attention-deficit hyperactivity disorder(ADHD)and ASD comorbidity(ASD and comorbidity group),and 104 children in the healthy physical examination group were selected from Jinhua City,and the contents of iron,zinc,copper,magnesium,calcium and lead of the three groups were detected and compared.Results The detection results of serum trace element levels in the ASD group and ASD and comorbidity group were worse than those in the control group,among which the changes of blood zinc,copper and lead contents were more obvious,and the abnormal rate of blood iron,zinc,copper,lead and calcium in ASD group was significantly higher than that in the control group,and the differences were statistically significant(P<0.05),and the difference in the abnormal rate of blood lead levels between the ASD group and the ASD and comorbidity group was statistically significant(P<0.05).Conclusion Changes in blood zinc,copper and lead levels may be one of the important factors leading to autism in children,and with the increase of abnormal blood lead levels,it will increase the risk of ASD children suffering from comorbid diseases such as ADHD.

关 键 词：自闭症 多动症 微量元素 共病性自闭症 

分 类 号：R927.2[医药卫生—药学]