Dual-Driven Hemostats Featured with Puncturing Erythrocytes for Severe Bleeding in Complex Wounds  

作　　者：Haoyu Qiu Guangqian Lan Weiwei Ding Xinyu Wang Wenyi Wang Dahua Shou Fei Lu Enling Hu Kun Yu Songmin Shang Ruiqi Xie 

机构地区：[1]State Key Laboratory of ilkworm Genome Biology,College of Sericulture,Textile and Biomass Sciences,Southwest University,Chongqing 400715,China [2]Chongqing Engineering Research Center of Biomaterial Fiber and Modern Textile,Chongqing 400715,China [3]Division of Trauma and Surgical Intensive Care Unit,Research Institute of General Surgery,Jinling Hospital,Medical School of Nanjing University,Nanjing,210002 Jiangsu Province,China [4]Institute of Textiles and Clothing,The Hong Kong Polytechnic University,Kowloon,Hong Kong

出　　处：《Research》2022年第4期119-135,共17页研究（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(No.52103096);Natural Science Foundation of Chongqing,China(grant number cstc2020jcyjmsxmX0383);Fundamental Research Funds for the Central Universities(grant number SWU-KT22004);Entrepreneurship and Innovation Program for Chongqing Overseas Returned Scholars(cx2019050);Innovation Project for Graduate Student of Chongqing(CYB21121).

摘　　要：Achieving rapid hemostasis in complex and deep wounds with secluded hemorrhagic sites is still a challenge because of the difficulty in delivering hemostats to these sites.In this study,a Janus particle,SEC-Fe@CaT with dual-driven forces,bubble-driving,and magnetic field–(MF–)mediated driving,was prepared via in situ loading of Fe_(3)O_(4) on a sunflower sporopollenin exine capsule(SEC),and followed by growth of flower-shaped CaCO3 clusters.The bubble-driving forces enabled SEC-Fe@CaT to self-diffuse in the blood to eliminate agglomeration,and the MF-mediated driving force facilitated the SEC-Fe@CaT countercurrent against blood to access deep bleeding sites in the wounds.During the movement in blood flow,the meteor hammer-like SEC from SEC-Fe@CaT can puncture red blood cells(RBCs)to release procoagulants,thus promoting activation of platelet and rapid hemostasis.Animal tests suggested that SEC-Fe@CaT stopped bleeding in as short as 30 and 45 s in femoral artery and liver hemorrhage models,respectively.In contrast,the similar commercial product Celox™required approximately 70 s to stop the bleeding in both bleeding modes.This study demonstrates a new hemostat platform for rapid hemostasis in deep and complex wounds.It was the first attempt integrating geometric structure of sunflower pollen with dual-driven movement in hemostasis.

关 键 词：driving BUBBLE eliminate 

分 类 号：R57[医药卫生—消化系统]