核因子E2相关因子2对脑出血继发性损伤调控机制研究进展  

The role of Nrf2 in the secondary brain injury after intracerebral hemorrhage

作　　者：徐伟 谢之易 王泽旭 马潞[1] 游潮[1] 胡鑫[1] XU Wei;XIE Zhi-yi;WANG Ze-xu;MA Lu;YOU Chao;HU Xin(Department of Neurosurgery,West China Hospital,Sichuan University,Chengdu 610041,Sichuan,China;Department of Neurosurgery,The Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,Zhejiang,China;Grade 2020,West China School of Medicine,Sichuan University,Chengdu 610041,Sichuan,China)

机构地区：[1]四川大学华西医院神经外科,成都610041 [2]浙江大学医学院附属第二医院神经外科,杭州310009 [3]四川大学华西临床医学院,成都610041

出　　处：《中国现代神经疾病杂志》2022年第10期836-840,共5页Chinese Journal of Contemporary Neurology and Neurosurgery

基　　金：国家自然科学基金青年科学基金资助项目(项目编号:81601155)。

摘　　要：脑出血的治疗迄今尚未取得突破性进展,如何减轻脑出血继发性损伤、改善患者预后,仍是亟待解决的重要课题。核因子E2相关因子2(Nrf2)作为抗氧化应激过程中关键转录因子,在脑出血继发性损伤的病理生理学机制中发挥重要作用。本文拟就Nrf2调控机制及其在脑出血继发性损伤中保护作用的研究进展进行综述,探讨其作为脑出血治疗靶点的可能性。Currently,there is still a lack of effective treatment options for intracerebral hemorrhage(ICH).It remains crucial to explore treatment to alleviate the secondary brain injury after ICH and improve the prognosis.Nuclear factor⁃erythroid 2⁃related factor 2(Nrf2)is the key transcriptional factor during oxidative stress.It also plays an important role in the secondary injury after ICH.This article reviews the regulatory mechanism of Nrf2 and its protective role in the secondary brain injury after ICH,to explore its possibility as a therapentic target.

关 键 词：核因子E2相关因子2(非MeSH词) 脑出血 脑损伤 氧化性应激 综述 

分 类 号：R743.34[医药卫生—神经病学与精神病学]