瑞舒伐他汀钙早期强化治疗短暂性脑缺血发作疗效分析  

Effect of early intensive treatment with rosuvastatin calcium on transient ischemic attack

作　　者：闵祖良 徐云磊 谢梦莹 MIN Zuliang;XU Yunlei;XIE Mengying(Emergency Department of Wuxi Ninth People's Hospital,Wuxi Jiangsu 214063,China)

机构地区：[1]无锡市第九人民医院急诊科,江苏无锡214063 [2]无锡市第九人民医院神经内科,江苏无锡214063

出　　处：《中国急救复苏与灾害医学杂志》2022年第12期1586-1589,共4页China Journal of Emergency Resuscitation and Disaster Medicine

基　　金：2017年江苏省卫生计生委医学科研课题(编号:N201705)。

摘　　要：目的探究瑞舒伐他汀钙早期强化治疗短暂性脑缺血发作的疗效。方法选取无锡市第九人民医院2019年4月—2021年2月收治的82例短暂性脑缺血发作患者作为研究对象。以电脑随机数法将其分为研究组和对照组,均41例,对照组予以阿司匹林、胞磷胆碱等基础治疗,研究组患者入院24 h内优先予以瑞舒伐他汀钙早期强化治疗,基础治疗同对照组。比较两组患者给药前及给药6个月后临床疗效、血脂指标水平、颈动脉粥样硬化水平、脑部血流指标水平及不良反应。结果研究组疗效优于对照组(P<0.05)。两组治疗后低密度脂蛋白、总胆固醇水平均低于治疗前,且研究组均低于对照组(P<0.05);两组治疗后高密度脂蛋白水平较治疗前均升高,且对照组低于研究组(P<0.05)。两组治疗后斑块面积及颈动脉内膜中层厚度均低于治疗前,且研究组低于对照组(P<0.05)。治疗后,两组平均血流量均高于治疗前,且研究组较对照组更高(P<0.05);两组治疗后脑血管床特性阻抗均低于治疗前,且研究组低于对照组(P<0.05)。两组不良反应发生率比较无统计学差异(P>0.05)。结论瑞舒伐他汀钙早期强化治疗短暂性脑缺血发作患者,可有效降低患者颈动脉内膜中层厚度及斑块面积,调节动脉粥样硬化水平及脑部血流量,降低血脂水平,临床疗效优越且安全性良好。Objective To explore the effect of early intensive treatment of rosuvastatin calcium on transient ischemic attack.Methods 82 patients with transient ischemic attack treated in Wuxi Ninth People’s Hospital from April 2019 to February 2021 were selected as the research object.They were divided into study group and control group by computer random number method,with 41 cases in each group.The control group was given basic treatment such as aspirin and citicoline.The patients in the study group were given early intensive treatment with rosuvastatin calcium within 24 hours after admission,and the basic treatment was the same as that in the control group.The clinical efficacy,blood lipid index level,carotid atherosclerosis level,cerebral blood flow index level and adverse reactions were compared between the two groups before and 6 months after administration.Results The curative effect of the study group was better than that of the control group(P<0.05).The levels of low density lipoprotein and total cholesterol in the two groups after treatment were lower than those before treatment,and those in the study group were lower than those in the control group(P<0.05).The level of HDL in the two groups after treatment was higher than that before treatment,and that in the control group was lower than that in the study group(P<0.05).The plaque area and carotid intima-media thickness in the two groups after treatment were lower than those before treatment,and those in the study group were lower than those in the control group(P<0.05).After treatment,the average blood flow of the two groups was higher than that before treatment,and the study group was higher than that of the control group(P<0.05).The characteristic impedance of cerebrovascular bed in the two groups after treatment was lower than that before treatment,and that in the study group was lower than that in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Rosuvastatin calcium

关 键 词：短暂性脑缺血 瑞舒伐他汀钙 血脂 动脉粥样硬化 

分 类 号：R743.31[医药卫生—神经病学与精神病学]