基于中西医临床病证特点的青光眼动物模型分析  

Analysis of Animal Models of Glaucoma Based on Characteristics of Clinical Symptoms of Traditional Chinese and Western Medicine

作　　者：李晓宇 梁丽娜[1] 高云 许凯[1] 李亚敏 LI Xiaoyu;LIANG Lina;GAO Yun;XU Kai;LI Yamin(Eye Disease Project Team of China Center for Evidence-Based Medicine of Chinese Medicine,Eye Hospital of China Academy of Chinese Medical Sciences,Beijing 100040,China)

机构地区：[1]中国中医科学院眼科医院,中国中医药循证医学中心眼科疾病项目组,北京100040

出　　处：《中国实验方剂学杂志》2022年第24期213-219,共7页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家自然科学基金项目(81973912,82274589);中国中医科学院科技创新工程项目(CI2021A02602);首都卫生发展科研专项项目(2020-2-4183);中国中医科学院委托项目(ZZ13-036-1);中国中医药循证医学中心“业务研究室主任专项”(2020YJSZX-2)。

摘　　要：青光眼是全球首位不可逆性致盲性眼病。当前青光眼动物模型主要根据是否存在高眼压,分为高眼压型与非高眼压视神经损伤型。该研究基于青光眼的中西医临床诊断标准及病证特点,对目前常见的青光眼动物模型的分类、造模方法、优缺点及中西医病证的吻合度进行归纳与分析。现有青光眼动物模型中激光光凝诱导型、前房注射物质诱导型、巩膜上静脉烙闭诱导型、环角巩膜缘缝合诱导型、转基因型等模型与西医诊断及中医眼部主证吻合度较高,说明现有模型可以较好地展现青光眼西医临床特点。但现有青光眼动物模型普遍对中医病因病机考虑较少,未观察中医四诊信息及证候特点,且尚未对病证结合青光眼动物模型开展研究。因此更加贴合临床实际的中西医病证结合青光眼动物模型的探索与建立有其必要性。该文旨在为青光眼病证结合动物模型探索统一的中西医诊断标准与评价体系,从临床最常见的青光眼肝郁证出发考虑如何体现中医证候特点,以期早日建立更加贴合临床、更具有中西医病症特点的青光眼病证结合动物模型,从而推动青光眼疾病更高质量的研究。Glaucoma is the first irreversible blinding eye disease in the world.The current animal models of glaucoma are mainly divided into ocular hypertension type and non-ocular hypertension optic nerve damage type according to the presence or absence of ocular hypertension.Based on the clinical diagnostic criteria and symptoms of glaucoma in traditional Chinese medicine(TCM)and western medicine,this study summarized and analyzed the classification,modeling methods,advantages and disadvantages of common animal models of glaucoma,and the degree of agreement between TCM and western medicine.Among the existing animal models of glaucoma,those induced by laser photocoagulation,anterior chamber injection,episcleral vein cauterization,and circumcorneal and scleral limbus suture,and transgenic models have a high degree of agreement with western medicine diagnosis and main eye syndromes in TCM,suggesting that the models available can ideally show the clinical characteristics of glaucoma in western medicine.However,the TCM etiology and pathogenesis are rarely considered in the existing animal models of glaucoma,and the information on four examinations and TCM syndrome characteristics have not been observed.Moreover,research on the combination of diseases and syndromes in animal models of glaucoma has not been carried out.Therefore,it is necessary to explore and establish an animal model of glaucoma with the combination of TCM and western medicine that is in line with clinical practice.This study aimed to explore unified diagnostic criteria and evaluation system of TCM and western medicine for animal models of glaucoma with syndrome-disease combination and considered how to reflect the characteristics of TCM syndromes based on glaucoma with liver depression syndrome to establish a glaucoma model with syndrome-disease combination in animals suitable for clinical practice with the characteristics of TCM and western medicine,thereby promoting higher-quality research on glaucoma.

关 键 词：青光眼 动物模型 临床病证 中西医 

分 类 号：R22[医药卫生—中医基础理论] R-332[医药卫生—中医学] R775R965.1