泛素-蛋白酶体系统在骨肉瘤中的研究进展  

Advances in the study of the ubiquitin proteasome system in osteosarcoma

作　　者：尹正宇 张懿明 刘红利[1] 张兵 仲新宇 曹文炳 张文超 李大鹏[1] Yin Zhengyu;Zhang Yiming;Liu Hongli;Zhang Bing;Zhong Xinyu;Cao Wenbing;Zhang Wenchao;Li Dapeng(Department of Orthopedics,Affiliated Hospital of Jiangsu University,Zhenjiang 212001,China)

机构地区：[1]江苏大学附属医院骨科,镇江212001

出　　处：《中华实验外科杂志》2022年第11期2259-2263,共5页Chinese Journal of Experimental Surgery

基　　金：江苏省高层次卫生人才"六个一工程"拔尖人才项目(LGY2019089);江苏省青年医学重点人才项目(QNRC2016844);江苏省研究生实践创新计划项目(SJCX19_0580);镇江市重点研发社会发展项目(SH2018036);江苏大学医教协同创新基金项目(JDY2022001)。

摘　　要：骨肉瘤(OS)是起源于间叶组织的最常见的原发性恶性骨肿瘤之一,它以耐药、复发、以及高转移率为临床特点。尽管在各种治疗措施的发展下其临床预后有所改善,但有转移的OS患者生存率仍不能令人满意。泛素-蛋白酶体系统(UPS)几乎存在于所有细胞事件中,尤其是在人类癌症的发生发展中起到关键作用。在过去的几年里,各种研究结果已经表明UPS在OS发展中起重要作用。在这篇综述里,我们将阐述UPS的组成部分及总结其近年在参与人类OS的发病机制中的进展,以期为OS的临床治疗提供新的思路。Osteosarcoma(OS)is one of the most common primary malignant bone tumours of mesenchymal origin and is characterised clinically by drug resistance,recurrence and a high rate of metastasis.Despite improvements in clinical prognosis with the development of various therapeutic measures,the survival rate of OS patients with metastases remains unsatisfactory.The ubiquitin-proteasome system(UPS)is present in almost all cellular events and plays a key role in the development of human cancers in particular.Over the past few years,various studies have demonstrated the pivotal role of the ubiquitin-proteasome system in the development of osteosarcoma.In this review,we describe the components of the ubiquitin proteasome system and summarise its recent involvement in the pathogenesis of human osteosarcoma,with the aim of providing new ideas for the clinical management of osteosarcoma.

关 键 词：泛素-蛋白酶体系统 骨肉瘤 E3连接酶 去泛素化酶 

分 类 号：R738.1[医药卫生—肿瘤]