记忆训练联合电针疗法对全脑放疗患者认知功能、健康相关生命质量和颅脑磁共振灌注成像参数的影响  

Effects of Memory Training Combined with Electroacupuncture Therapy on Cognitive Function,Health-Related Quality of Life and Brain Magnetic Resonance Perfusion Imaging Parameters in Patients with Whole Brain Radiotherapy

作　　者：陈莺[1,2] 林敏 徐永萍[1] 张利[1] 王佳若[1] 蒋维 CHEN Ying;LIN Min;XU Yong-ping;ZHANG Li;WANG Jia-ruo;JIANG Wei(Department of Oncology,Affiliated Hospital of Jiangnan University,Wuxi,Jiangsu,214061,China;Medical College of Jiangnan University,Wuxi,Jiangsu,214122,China;Department of Acupuncture,Affiliated Hospital of Jiangnan University,Wuxi,Jiangsu,214061,China)

机构地区：[1]江南大学附属医院肿瘤科,江苏无锡214061 [2]江南大学医学院,江苏无锡214122 [3]江南大学附属医院针灸科,江苏无锡214061

出　　处：《现代生物医学进展》2022年第22期4347-4350,4384,共5页Progress in Modern Biomedicine

基　　金：江苏省自然科学基金项目(BK20171107);无锡市卫生健康委员会资助项目(MS201928)。

摘　　要：目的:探讨记忆训练联合电针疗法对全脑放疗患者认知功能、健康相关生命质量和颅脑磁共振灌注成像参数的影响。方法:选择江南大学附属医院2020年3月~2022年1月期间收治的全脑放疗患者94例,根据随机数字表法分为研究组(常规干预、记忆训练联合电针疗法)和对照组(常规干预),各为47例。对比两组认知功能、健康相关生命质量和颅脑磁共振灌注成像参数的变化。结果:治疗1周、2周、3周、4周后,两组蒙特利尔认知功能检查量表(MoCA)和简易精神状态量表(MMSE)评分均较治疗前逐渐下降,但研究组各时间点MoCA、MMSE评分高于对照组(P<0.05)。治疗4周后,两组健康相关生命质量量表(HRQoL)各维度评分及总分均较治疗前升高,且研究组上述评分均高于对照组(P<0.05)。治疗4周后,两组颅脑平均脑血容量(CBV)值和平均脑血流量(CBF)值均较治疗前下降,但研究组上述值高于对照组(P<0.05)。结论:记忆训练联合电针疗法可减缓全脑放疗后导致的认知功能损害,并提升患者的健康相关生命质量,可能与调节脑血容量、脑血流量有关。Objective:To investigate the effects of memory training combined with electroacupuncture therapy on cognitive function,health-related quality of life and brain magnetic resonance perfusion imaging parameters in patients with whole brain radiotherapy.Methods:94 patients with whole brain radiotherapy who were treated in Affiliated Hospital of Jiangnan University from March 2020 to January 2022 were selected,and they were randomly divided into the study group(routine intervention,memory training combined with electroacupuncture therapy)and the control group(routine intervention),47 cases each.The changes of cognitive function,health-related quality of life and brain magnetic resonance perfusion imaging parameters were compared between the two groups.Results:1 week,2 weeks,3 week and 4 weeks after treatment,the scores of Montreal Cognitive Function Scale(MoCA)and Mini-Mental State Examination(MMSE)in two groups decreased gradually compared with those before treatment,but the scores of Mo CA and MMSE in the study group at each time point were higher than those in the control group(P<0.05).4 weeks after treatment,the scores and total scores of all dimensions of the health-related quality of life scale(HRQoL)in two groups were higher than those before treatment,and the above scores in the study group were higher than those in the control group(P<0.05).4 weeks after treatment,mean cerebral blood volume(CBV)and mean cerebral blood flow(CBF)in two groups were decreased compared with those before treatment,but those in the study group were higher than those in the control group(P<0.05).Conclusion:Memory training combined with electroacupuncture therapy can alleviate the cognitive impairment caused by whole brain radiotherapy and improve the health-related quality of life of patients,which may be related to the regulation of cerebral blood volume and cerebral blood flow.

关 键 词：记忆训练 电针疗法 全脑放疗 认知功能 健康相关生命质量 颅脑磁共振灌注成像参数 

分 类 号：R730.41[医药卫生—肿瘤] R493[医药卫生—临床医学]