Targeting p85β nuclear translocation for the tumors with PIK3CA helical domain mutations  

作　　者：Baoyu He Yujun Hao 

机构地区：[1]State Key Laboratory of Oncogenes and Related Genes,Shanghai Cancer Institute,Renji Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200032,PR China [2]Department of Laboratory Medicine,Affiliated Hospital of Jining Medical University,Jining Medical University,Jining,Shandong 272029,PR China

出　　处：《Genes & Diseases》2022年第6期1391-1393,共3页基因与疾病（英文）

基　　金：This work was supported by National Natural Science Foundation of China(No.82073044,and 81772503).

摘　　要：Phosphatidylinositol 3-kinases(PI3Ks)play key roles in tumorigenesis.PIK3CA,which encodes PI3K complex catalytic subunit p110a,is one of the most frequently mutated oncogenes in human cancers.1 So,targeting p110a holds great promise for cancer therapy.

关 键 词：PIK3CA Helical domain mutation p85β EZH2 USP7 

分 类 号：R730.5[医药卫生—肿瘤]