Pro-senescence neddylation inhibitor combined with a senescence activated β-galactosidase prodrug to selectively target cancer cells  

作　　者：Shuaishuai Ni Qian Liu Xin Chen Lele Ding Lili Cai Fei Mao Donglei Shi Robert M.Hoffman Jian Li Lijun Jia 

机构地区：[1]Cancer Institute,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,200032 Shanghai,China [2]State Key Laboratory of Bioreactor Engineering,Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism,Frontiers Science Center for Materiobiology and Dynamic Chemistry,Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and Technology,200037 Shanghai,China [3]Department of Surgery,University of California,San Diego,CA,USA

出　　处：《Signal Transduction and Targeted Therapy》2022年第10期3645-3648,共4页信号转导与靶向治疗（英文）

基　　金：supported by the National Natural Science Foundation of China(Grant Nos.81820108022,22177076,22037002);Innovation Program of Shanghai Municipal Education Commission(2019-01-07-00-10-E00056,2021-01-07-00-02-E00104);The Scientific and Technological Innovation Action Plan of Science and Technology Commission of Shanghai(20JC1411300);Shanghai Frontiers Science Center of Disease and Syndrome Biology of Inflammatory Cancer Transformation(2021KJ03-12);National Thirteenth Five-Year Science and Technology Major Special Project for New Drug and Development(2017ZX09304001);the Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism(2021 Sci&Tech 03-28);the Innovative Research Team of High-level Local Universities in Shanghai and the Chinese Special Fund for State Key Laboratory of Bioreactor Engineering(2060204).

摘　　要：Dear Editor,Targeting senescence therapy is a promising anticancer strategy by arresting the cell-cycle and inducing cellular senescence.However,senescent cells can promote malignancy and drug resistance.1,2 Thus,with the induction of senescence emerged as a viable therapeutic concept,it is important to consider how to eliminate those senescent cancer cells.

关 键 词：viable cancer eliminate 

分 类 号：R730.5[医药卫生—肿瘤]